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Incidence and Risk Factors of Recurrent Venous Thromboembolism after Pulmonary Embolism

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Author(s)
Hun-Gyu HwangWon-Il ChoiBora LeeChoong Won Lee
Keimyung Author(s)
Choi, Won Il
Department
Dept. of Internal Medicine (내과학)
Journal Title
Tuberculosis and Respiratory Diseases
Issued Date
2019
Volume
82
Issue
4
Keyword
Pulmonary EmbolismRecurrenceVenous Thromboembolism
Abstract
Background:
Information about the epidemiology of venous thromboembolism (VTE) recurrence in Korea is lacking. The purpose of this study was to investigate VTE cumulative recurrence rates and identify risk factors for VTE recurrence among Korean adults.

Methods:
A retrospective cohort study was conducted on adult patients (≥18 years) admitted to a university teaching hospital for pulmonary embolism (PE) from 2005 to 2013. The main outcome of interest was a recurrence of VTE. We used Cox proportional hazard regression analyses to calculate the relative risk of VTE recurrence.

Results:
Five-year cumulative incidence of recurrent VTE events was 21.5% (95% confidence interval [CI], 17.7–25.4) in all cases of PE; 17% after provoked and 27% after unprovoked PE. Multivariate analysis showed that body mass index (BMI) of ≥25 (hazard ratio [HR], 2.02; 95% CI, 1.17–3.46; p=0.01) and longer anticoagulation therapy duration (HR, 0.90; 95% CI, 0.84–0.96; p<0.01) were independently associated with risk of VTE recurrence. Risk factors not found to be statistically significant at the <0.05 level included history of VTE (HR, 1.81; 95% CI, 0.84–3.88; p=0.12), unprovoked PE (HR, 1.70; 95% CI, 0.89–3.25; p=0.10), symptomatic deep vein thrombosis (HR, 1.62; 95% CI, 0.89–2.94; p=0.10), and female sex (HR, 1.42; 95% CI, 0.78–2.55; p=0.24). We found that age, history of cancer, and other co-morbidities did not significantly affect the risk of VTE recurrence.

Conclusion:
Recurrence of VTE after PE is high. Patients with BMI ≥25 or reduced anticoagulation therapy duration have a higher risk of recurrent VTE.
Keimyung Author(s)(Kor)
최원일
Publisher
School of Medicine (의과대학)
Citation
Hun-Gyu Hwang et al. (2019). Incidence and Risk Factors of Recurrent Venous Thromboembolism after Pulmonary Embolism. Tuberculosis and Respiratory Diseases, 82(4), 341–347. doi: 10.4046/trd.2019.0019
Type
Article
ISSN
2005-6184
Source
https://e-trd.org/search.php?where=aview&id=10.4046/trd.2019.0019&code=0003TRD&vmode=FULL
DOI
10.4046/trd.2019.0019
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42465
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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