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Clinical Characteristics and Outcomes of Non-small Cell Lung Cancer Patients with HER2 Alterations in Korea

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Author(s)
Kangkook LeeHyun Ae JungJong-Mu SunSe-Hoon LeeJin Seok AhnKeunchil ParkMyung-Ju Ahn
Keimyung Author(s)
Lee, Kang Kook
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer Research and Treatment
Issued Date
2020
Volume
52
Issue
1
Keyword
Non-small cell lung cancerHER2 mutationHER2 amplification
Abstract
Purpose:
Human epidermal growth factor receptor 2 (HER2) alterations are found in approximately 1%-3% of non-small cell lung cancers (NSCLCs). We evaluated the clinical features and outcomes of NSCLC harboring HER2 alteration detected by next-generation sequencing (NGS) in Korea.

Materials and Methods:
A total of 1,108 patients who were diagnosed with NSCLC between December 2015 and December 2017 were screened and analyzed by NGS. Medical records were reviewed retrospectively to analyze the clinical characteristics and outcomes from various treatments.

Results:
HER2 alterations were identified in 36 NSCLC patients. Of the patients, 22 (61.1%) had an exon 20 in-frame insertion mutation, 15 (41.7%) had HER2 amplification, and one had both. The median patient age was 58 years, 55.6% were male, and 50.0% were neversmokers. Adenocarcinoma was predominant (88.9%). The most common metastatic site was bone (58.3%), and 66.7% of patients were stage IV at initial diagnosis. Six patients (16.7%) had a coexistent sensitizing epidermal growth factor receptor (EGFR) mutation, and two patients (5.6%) had anaplastic lymphoma kinase (ALK) rearrangement. With a median 14 months of follow-up, the median progression-free survival of first-line treatment was 6 months (95% confidence interval, 4.172 to 7.828), and median overall survival was not reached. The proportions of adenocarcinoma, never-smokers, and metastasis to the liver were higher in the exon 20 in-frame insertion mutation group, whereas coexistence of EGFR mutation was more frequently found in the HER2 amplification group.

Conclusion:
HER2-altered NSCLC showed distinct clinical features. Moreover, different characteristics were identified between the HER2 in-frame insertion mutation group and the HER2 amplification group.
Keimyung Author(s)(Kor)
이강국
Publisher
School of Medicine (의과대학)
Citation
Kangkook Lee et al. (2020). Clinical Characteristics and Outcomes of Non-small Cell Lung Cancer Patients with HER2 Alterations in Korea. Cancer Research and Treatment, 52(1), 292–300. doi: 10.4143/crt.2019.186
Type
Article
ISSN
2005-9256
Source
https://www.e-crt.org/journal/view.php?number=3025
DOI
10.4143/crt.2019.186
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42541
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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