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Clinical Characteristics of Clear Cell Ovarian Cancer: A Retrospective Multicenter Experience of 308 Patients in South Korea

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Author(s)
Hee Yeon LeeJi Hyung HongJae Ho ByunHee-Jun KimJin Young KimKi Hyang KimJina YunJung A KimKwonoh ParkHyo Jin LeeJung Lim LeeYoung-Woong WonIl Hwan KimWoo Kyun BaeKyong Hwa ParkDer-Sheng SunSun Kyung BaekSuee LeeMin-Young LeeGuk Jin LeeSook Hee HongYun Hwa JungHo Jung An
Keimyung Author(s)
Kim, Jin Young
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer Research and Treatment
Issued Date
2020
Volume
52
Issue
1
Keyword
Ovarian epithelial carcinomaClear cell adenocarcinomaKoreaAdjuvant chemotherapy
Abstract
Purpose:
The purpose of this study was to evaluate clinical characteristics and treatment pattern of ovarian clear cell carcinoma (OCCC) in Korea and the role of adjuvant chemotherapy in early-stage.

Materials and Methods:
Medical records of 308 cases of from 21 institutions were reviewed and data including age, performance status, endometriosis, thromboembolism, stage, cancer antigen 125, treatment, recurrence, and death were collected.

Results:
Regarding stage of OCCC, it was stage I in 194 (63.6%), stage II in 34 (11.1%), stage III in 66 (21.6%), and stage IV in 11 (3.6%) patients. All patients underwent surgery. Optimal surgery (residual disease ≤ 1 cm) was achieved in 89.3%. Majority of patients (80.5%) received postoperative chemotherapy. The most common regimen was taxane-platinum combination (96%). Median relapse-free survival (RFS) was 138.5 months for stage I, 33.4 for stage II, 19.3 for stage III, and 9.7 for stage IV. Median overall survival (OS) were not reached, 112.4, 48.7, and 18.3 months for stage I, II, III, and IV, respectively. Early-stage (stage I), endometriosis, and optimal debulking were identified as favorable prognostic factors for RFS. Early-stage and optimal debulking were also favorable prognostic factors for OS. Majority of patients with early-stage received adjuvant chemotherapy. However, additional survival benefit was not found in terms of recurrence.

Conclusion:
Majority of patients had early-stage and received postoperative chemotherapy regardless of stage. Early-stage and optimal debulking were identified as favorable prognostic factors. In stage IA or IB, adding adjuvant chemotherapy did not show difference in survival. Further study focusing on OCCC is required.
Keimyung Author(s)(Kor)
김진영
Publisher
School of Medicine (의과대학)
Citation
Hee Yeon Lee et al. (2020). Clinical Characteristics of Clear Cell Ovarian Cancer: A Retrospective Multicenter Experience of 308 Patients in South Korea. Cancer Research and Treatment, 52(1), 277–283. doi: 10.4143/crt.2019.292
Type
Article
ISSN
2005-9256
Source
https://www.e-crt.org/journal/view.php?number=3023
DOI
10.4143/crt.2019.292
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42542
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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