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The cellular function of SCAP in metabolic signaling

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Author(s)
Sun Hee LeeJae-Ho LeeSeung-Soon Im
Keimyung Author(s)
Lee, Jae HoIm, Seung Soon
Department
Dept. of Anatomy (해부학)
Dept. of Physiology (생리학)
Journal Title
Experimental and Molecular Medicine
Issued Date
2020
Volume
52
Abstract
Sterol regulatory element binding protein (SREBP) cleavage activating protein (SCAP) is a key regulator of SREBP maturation. SCAP induces translocation of SREBP from the endoplasmic reticulum to the Golgi apparatus, allowing it to regulate cellular triglyceride and cholesterol levels. Previous studies have shown that suppression of SREBP activation in SCAP conditional knockout mice reduced the accumulation of intracellular triglycerides, which eventually causes the development of metabolic diseases such as atherosclerosis, diabetes, hepatic steatosis, and insulin resistance. However, despite the significance of SCAP as a regulator of SREBP, its function has not been thoroughly discussed. In this review, we have summarized the function of SCAP and its regulatory proteins. Furthermore, we discuss recent studies regarding SCAP as a possible therapeutic target for hypertriglyceridemia and hyperlipidemia.
Keimyung Author(s)(Kor)
이재호
임승순
Publisher
School of Medicine (의과대학)
Citation
Sun Hee Lee et al. (2020). The cellular function of SCAP in metabolic signaling. Experimental and Molecular Medicine, 52, 724–729–724–729. doi: 10.1038/s12276-020-0430-0
Type
Article
ISSN
2092-6413
Source
https://www.nature.com/articles/s12276-020-0430-0
DOI
10.1038/s12276-020-0430-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42755
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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