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Nationwide Multicenter Study of Eosinophilic Esophagitis in Korean Children

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Author(s)
Kunsong LeeByung-Ho ChoeBen KangSeung KimJae Young KimJung Ok ShimYoo Min LeeEun Hye LeeHyo-Jeong JangEell RyooHye Ran Yang
Keimyung Author(s)
Jang, Hyo Jeong
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Pediatric Gastroenterology, Hepatology & Nutrition
Issued Date
2020
Volume
23
Issue
3
Keyword
Eosinophilic esophagitisEosinophilic gastroenteritisIncidenceChild
Abstract
Purpose:
In East Asian countries, there are only a few epidemiologic studies of eosinophilic esophagitis (EoE) and no studies in children. We investigated the incidence and compared the clinical characteristics of EoE and eosinophilic gastroenteritis involving the esophagus (EGEIE) in Korean children.

Methods:
A total of 910 children, who had symptoms of esophageal dysfunction, from 10 hospitals in Korea were included. EoE was diagnosed according to diagnostic guidelines and EGEIE was diagnosed when there were >15 eosinophils in the esophagus per high power field (HPF) and >20 eosinophils per HPF deposited in the stomach and duodenum with abnormal endoscopic findings.

Results:
Of the 910 subjects, 14 (1.5%) were diagnosed with EoE and 12 (1.3%) were diagnosed with EGEIE. Vomiting was the most common symptom in 57.1% and 66.7% of patients with EoE and EGEIE, respectively. Only diarrhea was significantly different between EoE and EGEIE (p=0.033). In total, 61.5% of patients had allergic diseases. Exudates were the most common endoscopic findings in EoE and there were no esophageal strictures in both groups. The median age of patients with normal endoscopic findings was significantly younger at 3.2 years, compared to the median age of 11.1 years in those with abnormal endoscopic findings (p=0.004).

Conclusion:
The incidence of EoE in Korean children was lower than that of Western countries, while the incidence of EGEIE was similar to EoE. There were no clinical differences except for diarrhea and no differences in endoscopic findings between EoE and EGEIE.
Keimyung Author(s)(Kor)
장효정
Publisher
School of Medicine (의과대학)
Citation
Kunsong Lee et al. (2020). Nationwide Multicenter Study of Eosinophilic Esophagitis in Korean Children. Pediatric Gastroenterology, Hepatology & Nutrition, 23(3), 231–242. doi: 10.5223/pghn.2020.23.3.231
Type
Article
ISSN
2234-8840
Source
https://www.pghn.org/search.php?where=aview&id=10.5223/pghn.2020.23.3.231&code=1121PGHN&vmode=FULL
DOI
10.5223/pghn.2020.23.3.231
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42769
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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