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The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea

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Author(s)
Mi Kyung KimJae-Han JeonSung-Woo KimJun Sung MoonNan Hee ChoEugene HanJi Hong YouJi Yeon LeeMiri HyunJae Seok ParkYong Shik KwonYeon-Kyung ChoiKi Tae KwonShin Yup LeeEon Ju JeonJin-Woo KimHyo-Lim HongHyun Hee KwonChi Young JungYin Young LeeEunyeoung HaSeung Min ChungJian HurJune Hong AhnNa-young KimShin-Woo KimHyun Ha ChangYong Hoon LeeJaehee LeeKeun-Gyu ParkHyun Ah KimJi-Hyun Lee
Keimyung Author(s)
Kim, Mi KyungCho, Nan HeeHan, Eu GeneYou, Ji HongLee, Ji YeonHyun, Mi RiPark, Jae SeokKwon, Yong ShikKim, Hyun Ah
Department
Dept. of Internal Medicine (내과학)
Journal Title
Diabetes and Metabolism Journal
Issued Date
2020
Volume
44
Issue
4
Keyword
COVID-19Diabetes mellitusMortalityPrognosis
Abstract
Background:
Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than eight million people worldwide by June 2020. Given the importance of the presence of diabetes mellitus (DM) for host immunity, we retrospectively evaluated the clinical characteristics and outcomes of moderate-to-severe COVID-19 in patients with diabetes.

Methods:
We conducted a multi-center observational study of 1,082 adult inpatients (aged ≥18 years) who were admitted to one of five university hospitals in Daegu because of the severity of their COVID-19-related disease. The demographic, laboratory, and radiologic findings, and the mortality, prevalence of severe disease, and duration of quarantine were compared between patients with and without DM. In addition, 1:1 propensity score (PS)-matching was conducted with the DM group.

Results:
Compared with the non-DM group (n=847), patients with DM (n=235) were older, exhibited higher mortality, and required more intensive care. Even after PS-matching, patients with DM exhibited more severe disease, and DM remained a prognostic factor for higher mortality (hazard ratio, 2.40; 95% confidence interval, 1.38 to 4.15). Subgroup analysis revealed that the presence of DM was associated with higher mortality, especially in older people (≥70 years old). Prior use of a dipeptidyl peptidase-4 inhibitor or a renin-angiotensin system inhibitor did not affect mortality or the clinical severity of the disease.

Conclusion:
DM is a significant risk factor for COVID-19 severity and mortality. Our findings imply that COVID-19 patients with DM, especially if elderly, require special attention and prompt intensive care.
Keimyung Author(s)(Kor)
김미경
조난희
한유진
유지홍
이지연
현미리
박재석
권용식
김현아
Publisher
School of Medicine (의과대학)
Citation
Mi Kyung Kim et al. (2020). The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea. Diabetes and Metabolism Journal, 44(4), 602–613. doi: 10.4093/dmj.2020.0146
Type
Article
ISSN
2233-6087
Source
https://www.e-dmj.org/journal/view.php?number=1739
DOI
10.4093/dmj.2020.0146
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42838
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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