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Clinical Approach to Autoimmune Epilepsy

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Author(s)
Yoonhyuk JangDong Wook KimKwang Ik YangJung-Ick ByunJong-Geun SeoYoung Joo NoKyung Wook KangDaeyoung KimKeun Tae KimYong Won ChoSoon-Tae Lee
Keimyung Author(s)
Kim, Keun TaeCho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of Clinical Neurology
Issued Date
2020
Volume
16
Issue
4
Keyword
autoimmune epilepsyautoimmune encephalitisNORSEautoimmune epilepsy treatmentautoimmune epilepsy immunotherapyrefractory status epilepticus
Abstract
Autoimmune epilepsy is a newly emerging area of epilepsy. The concept of "autoimmune" as an etiology has recently been revisited thanks to advances in autoimmune encephalitis and precision medicine with immunotherapies. Autoimmune epilepsy presents with specific clinical manifestations, and various diagnostic approaches including cerebrospinal fluid analysis, neuroimaging, and autoantibody tests are essential for its differential diagnosis. The diagnosis is often indeterminate despite performing a thorough evaluation, and therefore empirical immunotherapy may be applied according to the judgment of the clinician. Autoimmune epilepsy often manifests as new-onset refractory status epilepticus (NORSE). A patient classified as NORSE should receive empirical immunotherapy as soon as possible. On the other hand, a morecautious, stepwise approach is recommended for autoimmune epilepsy that presents with episodic events. The type of autoimmune epilepsy is also an important factor to consider when choosing from among various immunotherapy options. Clinicians should additionally take the characteristics of antiepileptic drugs into account when using them as an adjuvant therapy. This expert opinion discusses the diagnostic and treatment approaches for autoimmune epilepsy from a practical point of view.
Keimyung Author(s)(Kor)
김근태
조용원
Publisher
School of Medicine (의과대학)
Citation
Yoonhyuk Jang et al. (2020). Clinical Approach to Autoimmune Epilepsy. Journal of Clinical Neurology, 16(4), 519–529. doi: 10.3988/jcn.2020.16.4.519
Type
Article
ISSN
2005-5013
Source
https://thejcn.com/search.php?where=aview&id=10.3988/jcn.2020.16.4.519&code=0145JCN&vmode=FULL
DOI
10.3988/jcn.2020.16.4.519
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42851
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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