Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): a Multicenter Cohort Study
- Author(s)
- Minkwan Kim; Jong-Ho Nam; Jang-Won Son; Sun Oh Kim; Nak-Hoon Son; Chul-Min Ahn; Chi Young Shim; Geu-Ru Hong; In-Cheol Kim; Jinwoo Choi; Seung-Mo Kang; Yeoung Ho Choi; Hae Kyoung Yoon; Jae-Sun Uhm; In Hyun Jung
- Keimyung Author(s)
- Kim, In Cheol
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- Journal of Korean Medical Science
- Issued Date
- 2020
- Volume
- 35
- Issue
- 40
- Keyword
- Coronavirus; COVID-19; Echocardiography; Global Longitudinal Strain; Ejection Fraction; Disease Severity
- Abstract
- Background:
This study aimed to investigate the cardiac manifestations of coronavirus disease 2019 (COVID-19).
Methods:
From February to March 2020, we prospectively and retrospectively enrolled consecutive patients diagnosed with COVID-19. Patient's data such as the demographic characteristics, symptoms, vital signs, laboratory and radiologic findings, electrocardiographic, and echocardiographic data, including the global longitudinal strain (GLS) of both ventricles, were obtained.
Results:
Forty patients (median age, 58 years; 50% men) were enrolled in the initial analysis. Patients were classified into severe and nonsevere groups based on the current guidelines. The 13 patients in the severe group were significantly older, had a greater prevalence of bilateral pneumonia and leukocytosis, and higher aspartate transaminase levels than patients in the nonsevere group. Patients in the severe group had a slightly lower left ventricular ejection fraction (LVEF) than those in the nonsevere group (median [interquartile range], 61.0% [58.5%, 62.3%] vs. 66.7% [60.6%, 69.8%], P = 0.015). In a subgroup of 34 patients in whom GLS could be analyzed, patients in the severe group had a significantly impaired left ventricular GLS (LVGLS) than those in the nonsevere group (−18.1% [−18.8%, −17.1%] vs. −21.7% [−22.9%, −19.9%], P = 0.001). There were no significant differences in total wall (RVGLStotal, −19.3% [−23.9%, −18.4%] vs. −24.3% [−26.0%, −22.6%], P = 0.060) and free wall (RVGLSfw, −22.7% [−27.2%, −18.6%] vs. −28.8% [−30.4%, −24.1%], P = 0.066) right ventricle GLS (RVGLS).
Conclusion:
Patients with severe COVID-19 had lower LVEF and LVGLS. RVGLS was not different between patients with severe and nonsevere COVID-19.
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