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Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): a Multicenter Cohort Study

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Author(s)
Minkwan KimJong-Ho NamJang-Won SonSun Oh KimNak-Hoon SonChul-Min AhnChi Young ShimGeu-Ru HongIn-Cheol KimJinwoo ChoiSeung-Mo KangYeoung Ho ChoiHae Kyoung YoonJae-Sun UhmIn Hyun Jung
Keimyung Author(s)
Kim, In Cheol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2020
Volume
35
Issue
40
Keyword
CoronavirusCOVID-19EchocardiographyGlobal Longitudinal StrainEjection FractionDisease Severity
Abstract
Background:
This study aimed to investigate the cardiac manifestations of coronavirus disease 2019 (COVID-19).

Methods:
From February to March 2020, we prospectively and retrospectively enrolled consecutive patients diagnosed with COVID-19. Patient's data such as the demographic characteristics, symptoms, vital signs, laboratory and radiologic findings, electrocardiographic, and echocardiographic data, including the global longitudinal strain (GLS) of both ventricles, were obtained.

Results:
Forty patients (median age, 58 years; 50% men) were enrolled in the initial analysis. Patients were classified into severe and nonsevere groups based on the current guidelines. The 13 patients in the severe group were significantly older, had a greater prevalence of bilateral pneumonia and leukocytosis, and higher aspartate transaminase levels than patients in the nonsevere group. Patients in the severe group had a slightly lower left ventricular ejection fraction (LVEF) than those in the nonsevere group (median [interquartile range], 61.0% [58.5%, 62.3%] vs. 66.7% [60.6%, 69.8%], P = 0.015). In a subgroup of 34 patients in whom GLS could be analyzed, patients in the severe group had a significantly impaired left ventricular GLS (LVGLS) than those in the nonsevere group (−18.1% [−18.8%, −17.1%] vs. −21.7% [−22.9%, −19.9%], P = 0.001). There were no significant differences in total wall (RVGLStotal, −19.3% [−23.9%, −18.4%] vs. −24.3% [−26.0%, −22.6%], P = 0.060) and free wall (RVGLSfw, −22.7% [−27.2%, −18.6%] vs. −28.8% [−30.4%, −24.1%], P = 0.066) right ventricle GLS (RVGLS).

Conclusion:
Patients with severe COVID-19 had lower LVEF and LVGLS. RVGLS was not different between patients with severe and nonsevere COVID-19.
Keimyung Author(s)(Kor)
김인철
Publisher
School of Medicine (의과대학)
Citation
Minkwan Kim et al. (2020). Cardiac Manifestations of Coronavirus Disease 2019 (COVID-19): a Multicenter Cohort Study. Journal of Korean Medical Science, 35(40), e366. doi: 10.3346/jkms.2020.35.e366
Type
Article
ISSN
1598-6357
Source
https://jkms.org/search.php?where=aview&id=10.3346/jkms.2020.35.e366&code=0063JKMS&vmode=FULL
DOI
10.3346/jkms.2020.35.e366
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42857
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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