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Clinical Characteristics and Treatment Outcomes in Children, Adolescents, and Young-adults with Hodgkin's Lymphoma: a KPHOG Lymphoma Working-party, Multicenter, Retrospective Study

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Author(s)
Jae Min LeeJung Yoon ChoiKyung Taek HongHyoung Jin KangHee Young ShinHee Jo BaekHoon KookSeongkoo KimJae Wook LeeNack-Gyun ChungBin ChoSeok-Goo ChoKyung Mi ParkEu Jeen YangYoung Tak LimJin Kyung SuhSung Han KangHyery KimKyung-Nam KohHo Joon ImJong Jin SeoHee Won ChoHee Young JuJi Won LeeKeon Hee YooKi Woong SungHong Hoe KooKyung Duk ParkJeong Ok HahMin Kyoung KimJung Woo HanSeung Min HahnChuhl Joo LyuYe Jee ShimHeung Sik KimYoung Rok DoJae Won YooYeon Jung LimIn-Sang JeonHee won ChuehSung Yong OhHyoung Soo ChoiJun Eun ParkJun Ah LeeHyeon Jin ParkByung-Kiu ParkSoon Ki KimJae Young LimEun Sil ParkSang Kyu ParkEun Jin ChoiYoung Bae ChoiJong Hyung Yoon
Keimyung Author(s)
Shim, Ye JeeKim, Heung SikDo, Young Rok
Department
Dept. of Pediatrics (소아청소년학)
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2020
Volume
35
Issue
46
Keyword
Hodgkin LymphomaChildrenAdolescentYoung AdultLate Complication
Abstract
Background:
Hodgkin's lymphoma (HL) constitutes 10%–20% of all malignant lymphomas and has a high cure rate (5-year survival, around 90%). Recently, interest has increased concerning preventing secondary complications (secondary cancer, endocrine disorders) in long-term survivors. We aimed to study the epidemiologic features and therapeutic outcomes of HL in children, adolescents, and young adults in Korea.

Methods:
We performed a multicenter, retrospective study of 224 patients aged < 25 years diagnosed with HL at 22 participating institutes in Korea from January 2007 to August 2016.

Results:
A higher percentage of males was diagnosed at a younger age. Nodular sclerosis histopathological HL subtype was most common, followed by mixed cellularity subtype. Eighty-one (36.2%), 101 (45.1%), and 42 (18.8%) patients were classified into low, intermediate, and high-risk groups, respectively. Doxorubicin, bleomycin, vinblastine, dacarbazine was the most common protocol (n = 102, 45.5%). Event-free survival rate was 86.0% ± 2.4%, while five-year overall survival (OS) rate was 96.1% ± 1.4%: 98.7% ± 1.3%, 97.7% ± 1.6%, and 86.5% ± 5.6% in the low, intermediate, and high-risk groups, respectively (P = 0.021). Five-year OS was worse in patients with B-symptoms, stage IV disease, high-risk, splenic involvement, extra-nodal lymphoma, and elevated lactate dehydrogenase level. In multivariate analysis, B-symptoms and extra-nodal involvement were prognostic factors for poor OS. Late complications of endocrine disorders and secondary malignancy were observed in 17 and 6 patients, respectively.

Conclusion:
This is the first study on the epidemiology and treatment outcomes of HL in children, adolescents, and young adults in Korea. Future prospective studies are indicated to develop therapies that minimize treatment toxicity while maximizing cure rates in children, adolescents, and young adults with HL.
Keimyung Author(s)(Kor)
심예지
김흥식
도영록
Publisher
School of Medicine (의과대학)
Citation
Jae Min Lee et al. (2020). Clinical Characteristics and Treatment Outcomes in Children, Adolescents, and Young-adults with Hodgkin’s Lymphoma: a KPHOG Lymphoma Working-party, Multicenter, Retrospective Study. Journal of Korean Medical Science, 35(46), e393. doi: 10.3346/jkms.2020.35.e393
Type
Article
ISSN
1598-6357
Source
https://jkms.org/search.php?where=aview&id=10.3346/jkms.2020.35.e393&code=0063JKMS&vmode=FULL
DOI
10.3346/jkms.2020.35.e393
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42861
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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