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Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January–May 2020

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Author(s)
Ho Kyung SungJin Yong KimJeonghun HeoHaesook SeoYoung soo JangHyewon KimBo Ram KohNeungsun JoHong Sang OhYoung Mi BaekKyung-Hwa ParkJeung A ShonMin-Chul KimJoon Ho KimHyun-Ha ChangYukyung ParkYu Min KangDong Hyun LeeDong Hyun OhHyun Jung ParkKyoung-Ho SongEun Kyoung LeeHyeongseok JeongJi Yeon LeeJa-Young KoJihee ChoiEun Hwa RyuKi-hyun ChungMyoung-don Oh
Keimyung Author(s)
Lee, Ji Yeon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2020
Volume
35
Issue
30
Keyword
COVID-19SARS-CoV-2PrognosisCohort StudyKorea
Abstract
Background:
The fatality rate of patients with coronavirus disease 2019 (COVID-19) varies among countries owing to demographics, patient comorbidities, surge capacity of healthcare systems, and the quality of medical care. We assessed the clinical outcomes of patients with COVID-19 during the first wave of the epidemic in Korea.

Methods:
Using a modified World Health Organization clinical record form, we obtained clinical data for 3,060 patients with COVID-19 treated at 55 hospitals in Korea. Disease severity scores were defined as: 1) no limitation of daily activities; 2) limitation of daily activities but no need for supplemental oxygen; 3) supplemental oxygen via nasal cannula; 4) supplemental oxygen via facial mask; 5) non-invasive mechanical ventilation; 6) invasive mechanical ventilation; 7) multi-organ failure or extracorporeal membrane oxygenation therapy; and 8) death. Recovery was defined as a severity score of 1 or 2, or discharge and release from isolation.

Results:
The median age of the patients was 43 years of age; 43.6% were male. The median time from illness onset to admission was 5 days. Of the patients with a disease severity score of 3–4 on admission, 65 (71.5%) of the 91 patients recovered, and 7 (7.7%) died due to illness by day 28. Of the patients with disease severity scores of 5–7, 7 (19.5%) of the 36 patients recovered, and 8 (22.2%) died due to illness by day 28. None of the 1,324 patients who were < 50 years of age died; in contrast, the fatality rate due to illness by day 28 was 0.5% (2/375), 0.9% (2/215), 5.8% (6/104), and 14.0% (7/50) for the patients aged 50–59, 60–69, 70–79, and ≥ 80 years of age, respectively.

Conclusion:
In Korea, almost all patients of < 50 years of age with COVID-19 recovered without supplemental oxygen. In patients of ≥ 50 years of age, the fatality rate increased with age, reaching 14% in patients of ≥ 80 years of age.
Keimyung Author(s)(Kor)
이지연
Publisher
School of Medicine (의과대학)
Citation
Ho Kyung Sung et al. (2020). Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January–May 2020. Journal of Korean Medical Science, 35(30), e280. doi: 10.3346/jkms.2020.35.e280
Type
Article
ISSN
1598-6357
Source
https://jkms.org/search.php?where=aview&id=10.3346/jkms.2020.35.e280&code=0063JKMS&vmode=FULL
DOI
10.3346/jkms.2020.35.e280
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42862
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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