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The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019

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Author(s)
In-Cheol KimJin Eun SongHee Jung LeeJeong-Ho ParkMiri HyunJi Yeon LeeHyun Ah KimYong Shik KwonJae Seok ParkJong-Chan YounJongmin HwangCheol Hyun LeeYun-Kyeong ChoHyoung-Seob ParkHyuck-Jun YoonChang-Wook NamSeongwook HanSeung-Ho HurHoward J. EisenHyungseop Kim
Keimyung Author(s)
Kim, In CheolSong, Jin EunLee, Hee JungPark, Jeong HoHyun, Mi RiLee, Ji YeonKim, Hyun AhKwon, Yong ShikPark, Jae SeokHwang, Jong MinLee, Cheol HyunCho, Yun KyeongPark, Hyoung SeobYoon, Hyuck JunNam, Chang WookHan, Seong WookHur, Seung HoKim, Hyung Seop
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Korean Medical Science
Issued Date
2020
Volume
35
Issue
39
Keyword
CoronavirusCOVID-19Cardiac Injury MarkersIn-hospital Mortality
Abstract
Backgrounds:
The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has spread worldwide. Cardiac injury after SARS-CoV-2 infection is a major concern. The present study investigated impact of the biomarkers indicating cardiac injury in coronavirus disease 2019 (COVID-19) on patients' outcomes.

Methods:
This study enrolled patients who were confirmed to have COVID-19 and admitted at a tertiary university referral hospital between February 19, 2020 and March 15, 2020. Cardiac injury was defined as an abnormality in one of the following result markers: 1) myocardial damage marker (creatine kinase-MB or troponin-I), 2) heart failure marker (N-terminal-pro B-type natriuretic peptide), and 3) electrical abnormality marker (electrocardiography). The relationship between each cardiac injury marker and mortality was evaluated. Survival analysis of mortality according to the scoring by numbers of cardiac injury markers was also performed.

Results:
A total of 38 patients with COVID-19 were enrolled. Twenty-two patients (57.9%) had at least one of cardiac injury markers. The patients with cardiac injuries were older (69.6 ± 14.9 vs. 58.6 ± 13.9 years old, P = 0.026), and were more male (59.1% vs. 18.8%, P = 0.013). They showed lower initial oxygen saturation (92.8 vs. 97.1%, P = 0.002) and a trend toward higher mortality (27.3 vs. 6.3%, P = 0.099). The increased number of cardiac injury markers was significantly related to a higher incidence of in-hospital mortality which was also evidenced by Kaplan-Meier survival analysis (P = 0.008).

Conclusion:
The increased number of cardiac injury markers is related to in-hospital mortality in patients with COVID-19.
Keimyung Author(s)(Kor)
김인철
송진언
이희정
박정호
현미리
이지연
김현아
권용식
박재석
황종민
이철현
조윤경
박형섭
윤혁준
남창욱
한성욱
허승호
김형섭
Publisher
School of Medicine (의과대학)
Citation
In-Cheol Kim et al. (2020). The Implication of Cardiac Injury Score on In-hospital Mortality of Coronavirus Disease 2019. Journal of Korean Medical Science, 35(39), e349. doi: 10.3346/jkms.2020.35.e349
Type
Article
ISSN
1598-6357
Source
https://jkms.org/search.php?where=aview&id=10.3346/jkms.2020.35.e349&code=0063JKMS&vmode=FULL
DOI
10.3346/jkms.2020.35.e349
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42867
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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