계명대학교 의학도서관 Repository

Characteristics of COVID-19 Patients Who Progress to Pneumonia on Follow-Up Chest Radiograph: 236 Patients from a Single Isolated Cohort in Daegu, South Korea

Metadata Downloads
Affiliated Author(s)
김진영이무숙이지연박재석현미리김현아권용식문성민
Alternative Author(s)
Kim, Jin YoungLee, Mu SookLee, Ji YeonPark, Jae SeokHyun, Mi RiKim, Hyun AhKwon, Yong ShikMoon, Sung Min
Journal Title
Korean Journal of Radiology
ISSN
2005-8330
Issued Date
2020
Keyword
RadiographyCoronavirusCOVID-19PneumoniaC-reactive proteinLymphopeniaLactate dehydrogenase
Abstract
Objective:
We investigated the prevalence of pneumonia in novel coronavirus disease 2019 (COVID-19) patients using chest radiographs to identify the characteristics of those with initially negative chest radiographs, who were positive for pneumonia on follow-up.

Materials and Methods:
Retrospective cohort data of 236 COVID-19 patients were reviewed. Chest radiography was performed on admission, with serial radiographs obtained until discharge. The 'positive conversion group' was defined as patients whose initial chest radiographs were negative but were positive for pneumonia during follow-up. Patients with initially positive chest radiographs were defined as the 'initial pneumonia group.' Patients with negative initial and follow-up chest radiographs were defined as the 'non-pneumonia group.' Clinical and laboratory findings were compared between groups, and predictors of positive conversion were investigated.

Results:
Among 236 patients, 108 (45.8%) were in the non-pneumonia group, 69 (29.2%) were in the initial pneumonia group, and 59 (25%) were in the positive conversion group. The patients in the 'initial pneumonia group' and 'positive conversion group' were older, had higher C-reactive protein (CRP) and lactate dehydrogenase levels, and lower absolute lymphocyte counts than those in the 'non-pneumonia group' (all p < 0.001). Among patients with negative initial chest radiographs, age ≥ 45 years (odds ratio [OR]: 3.93, 95% confidence interval [CI]: 1.76–8.75, p = 0.001), absolute lymphocyte count < 1500 cells/µL (OR: 2.25, 95% CI: 1.03–4.89, p = 0.041), and CRP > 0.5 mg/dL (OR: 3.91, 95% CI: 1.54–9.91, p = 0.004) were independent predictors for future development of pneumonia.

Conclusion:
More than a half of COVID-19 patients initially had normal chest radiographs; however, elderly patients (≥ 45 years of age) with abnormal laboratory findings (elevated CRP and low absolute lymphocyte counts) developed pneumonia on follow-up radiographs.
Department
Dept. of Radiology (영상의학)
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
Ha Kyung Jung et al. (2020). Characteristics of COVID-19 Patients Who Progress to Pneumonia on Follow-Up Chest Radiograph: 236 Patients from a Single Isolated Cohort in Daegu, South Korea. Korean Journal of Radiology, 21(11), 1265–1272. doi: 10.3348/kjr.2020.0564
Type
Article
ISSN
2005-8330
DOI
10.3348/kjr.2020.0564
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42878
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.