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Prevalence of osteoporosis in patients with systemic lupus erythematosus: A multicenter comparative study of the World Health Organization and fracture risk assessment tool criteria

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Author(s)
Ju-Yang JungSang Tae ChoiSung-Hoon ParkSeong-Ryul KwonHyoun-Ah KimSung-Soo KimSang Hyon KimChang-Hee Suh
Keimyung Author(s)
Kim, Sang Hyon
Department
Dept. of Internal Medicine (내과학)
Journal Title
Osteoporosis and Sarcopenia
Issued Date
2020
Volume
6
Issue
4
Keyword
Systemic lupus erythematosusOsteoporosisFractureBone mineral densityFracture risk assessment tool
Abstract
Objectives
Osteoporosis and fracture are known complications of systemic lupus erythematosus (SLE). We assessed the prevalence and risk factors for osteoporosis in patients with SLE.

Methods
A total of 155 female SLE patients were recruited retrospectively in 5 university hospitals. The bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry, and the fracture risk assessment tool (FRAX) for high-risk osteoporotic fractures was calculated with and without BMD.

Results
The mean age was 53.7 ± 6.8 years, and osteoporotic fractures were detected in 19/127 (15.0%) patients. The proportion of patients having a high-risk for osteoporotic fractures in the FRAX with and without BMD, and osteoporosis by the World Health Organization (WHO) criteria were 25 (16.1%), 24 (15.5%), and 51 (32.9%), respectively, and 48.0–68.6% of them were receiving treatment. On multivariate logistic analysis, nephritis (odds ratio [OR] 11.35) and cumulative dose of glucocorticoid (OR 1.1) were associated with high-risk by the FRAX with BMD, and low complement levels (OR 4.38), erythrocyte sedimentation rate (ESR) (OR 1.04), and cumulative dose of glucocorticoid (OR 1.05) were associated with osteoporosis by the WHO criteria in patients with SLE.

Conclusions
Among Korean female patients with SLE, the proportion of patients having a high-risk of osteoporotic fractures by the FRAX tool was 15.5%–16.1% and the proportion of patients having osteoporosis by the WHO criteria was 32.9%. In SLE, nephritis, low level of complement, ESR, and cumulative dose of glucocorticoids may contribute to fracture risk.
Keimyung Author(s)(Kor)
김상현
Publisher
School of Medicine (의과대학)
Citation
Ju-Yang Jung et al. (2020). Prevalence of osteoporosis in patients with systemic lupus erythematosus: A multicenter comparative study of the World Health Organization and fracture risk assessment tool criteria. Osteoporosis and Sarcopenia, 6(4), 173–178. doi: 10.1016/j.afos.2020.11.001
Type
Article
ISSN
2405-5255
Source
https://www.sciencedirect.com/science/article/pii/S2405525520301011
DOI
10.1016/j.afos.2020.11.001
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42885
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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