계명대학교 의학도서관 Repository

The clinical and economic burden of communityonset complicated skin and skin structure infections in Korea

Metadata Downloads
Author(s)
Yong Kyun ChoHeung Jeong WooShin Woo KimIn-Gyu BaeYoung Goo SongHee Jin CheongHyuck LeeSang Hoon HanHee Jung ChoiChisook MoonSeong Yeol RyuJian HurJa Cob LeeYu Mi JoYoung Joo Kim
Keimyung Author(s)
Ryu, Seong Yeol
Department
Dept. of Internal Medicine (내과학)
Journal Title
The Korean Journal of Internal Medicine
Issued Date
2020
Volume
35
Issue
6
Keyword
Complicated skin and skin structure infectionEconomicClinical burdenInitial antibiotics
Abstract
Background/Aims:
To investigate epidemiologic characteristics, clinical and economic burdens, and factors associated with mortality in complicated skin and skin structure infection (cSSSI) patients in Korea.

Methods:
A retrospective, observational, nationwide study was conducted between April to July 2012 at 14 tertiary-hospitals in Korea. Eligible patients were hospitalized adults with community acquired cSSSI, who underwent surgical intervention and completed treatment between November 2009 and October 2011. Data on demography, clinical characteristics, outcomes and medical resource utilization were collected through medical record review. Direct medical costs were calculated by multiplying quantities of resources utilized by each unit price in Korea.

Results:
Of 473 patients enrolled, 449 patients (except 24 patients with no record on surgical intervention) were eligible for analysis. Microbiological testing was performed on 66.1% of patients and 8.2% had multiple pathogens. Among culture confirmed pathogens (n = 297 patients, 340 episodes), 76.2% were gram-positive (Staphylococcus aureus; 41.2%) and 23.8% were gram-negative. The median duration of hospital stay was 16 days. Among treated patients, 3.3% experienced recurrence and 4.2% died in-hospital. The mean direct medical costs amounted to $4,195/ person, with the greatest expenses for hospitalization and antibiotics. The in-hospital mortality and total medical costs were higher in combined antibiotics therapy than monotherapy (p < 0.05). Charlson's comorbidity index ≥ 3, standardized early warning scoring ≥ 4, sub-fascia infections and combined initial therapy, were all found to be associated with higher mortality.

Conclusions:
Korean patients with community-onset cSSSI suffer from considerable clinical and economic burden. Efforts should be made to reduce this burden through appropriate initial treatment.
Keimyung Author(s)(Kor)
류성열
Publisher
School of Medicine (의과대학)
Citation
Yong Kyun Cho et al. (2020). The clinical and economic burden of communityonset complicated skin and skin structure infections in Korea. The Korean Journal of Internal Medicine, 35(6), 1497–1506. doi: 10.3904/kjim.2018.374
Type
Article
ISSN
2005-6648
Source
https://www.kjim.org/journal/view.php?number=170301
DOI
10.3904/kjim.2018.374
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42888
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.