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Cypress Essential Oil Improves Scopolamine-induced Learning and Memory Deficit in C57BL/6 mice

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Author(s)
Gil-Yong LeeChan LeeJeong-In BaekKeunyoung BaeChan-Ik ParkJung-Hee Jang
Keimyung Author(s)
Jang, Jung Hee
Department
Dept. of Pharmacology (약리학)
Journal Title
대한본초학회지
Issued Date
2020
Volume
35
Issue
5
Keyword
brain-derived neurotrophic factorcAMP response element binding proteincypress essential oillearning and memory impairmentscopolamine
Abstract
Objectives :
Increasing evidence supports the biological and pharmacological activities of essential oils on the central nervous system such as pain, anxiety, attention, arousal, relaxation, sedation and learning and memory. The purpose of present work is to investigate the protective effect and molecular mechanism of cypress essential oil (CEO) against scopolamine (SCO)-induced cognitive impairments in C57BL/6 mice.

Methods :
A series of behavior tests such as Morris water maze, passive avoidance, and fear conditioning tests were conducted to monitor learning and memory functions. Immunoblotting and RT-PCR were also performed in the hippocampal tissue to determine the underlying mechanism of CEO.

Results :
SCO induced cognitive impairments as assessed by decreased step-through latency in passive avoidance test, relatively low freezing time in fear conditioning test, and increased time spent to find the hidden platform in Morris water maze test. Conversely, CEO inhalation significantly reversed the SCO-induced cognitive impairments in C57BL/6 mice comparable to control levels. To elucidate the molecular mechanisms of memory enhancing effect of CEO we have examined the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. CEO effectively elevated the protein as well as mRNA expression of BDNF via activation of cAMP response element binding protein (CREB).

Conclusions :
Our findings suggest that CEO inhalation effectively restored the SCO-impaired cognitive functions in C56BL/6 mice. This learning and memory enhancing effect of CEO was partly mediated by up-regulation of BDNF via activation of CREB.
Alternative Title
사이프러스 에센셜 오일의 흡입이 전임상 실험동물의 손상된 학습능력과 기억력에 미치는 영향
Keimyung Author(s)(Kor)
장정희
Publisher
School of Medicine (의과대학)
Citation
Gil-Yong Lee et al. (2020). Cypress Essential Oil Improves Scopolamine-induced Learning and Memory Deficit in C57BL/6 mice. 대한본초학회지, 35(5), 33–39. doi: 10.6116/kjh.2020.35.5.33.
Type
Article
ISSN
2288-7199
Source
https://www.koreascience.or.kr/article/JAKO202028662597386.page
DOI
10.6116/kjh.2020.35.5.33.
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42898
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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