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Elevated Serum Leptin Receptor and Insulin-like Growth Factor-1 Levels and High Levels of Leptin Receptor Expression in Acanthosis Nigricans Patients: Serologic and Histopathologic Analyses

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Author(s)
Won-Oh KimHyun-Wook KimHyun-Jae JoeYoung-Wook RyooHye-Ra JungSung-Ae Kim
Keimyung Author(s)
Ryoo, Young WookJung, Hye RaKim, Sung Ae
Department
Dept. of Dermatology (피부과학)
Dept. of Pathology (병리학)
Journal Title
대한피부과학회지
Issued Date
2020
Volume
58
Issue
8
Keyword
Acanthosis nigricansAdipokineInsulin-like growth factor-1LeptinLeptin receptor
Abstract
Background:
Acanthosis nigricans is characterized by a velvety thickening of the epidermis accompanied by different degrees of hyperpigmentation, and known to be linked to obesity and insulin resistance.

Objective:
We aimed to analyze obesity-related factors in acanthosis nigricans patients and to evaluate the correlations between acanthosis nigricans and various factors.

Methods:
From January 2004 to February 2015, 27 acanthosis nigricans patients participated in this study. Blood samples were collected from a control group of seven overweight people and from the seven acanthosis nigricans patients, and they were analyzed for different obesity-related factors. Skin samples were collected from the 23 acanthosis nigricans patients and from 11 patients with epidermal nevi, and immunohistochemistry was performed to detect the presence of adiponectin receptor 1, adiponectin receptor 2, and the leptin receptor.

Results:
The median serum leptin level in the acanthosis nigricans patients (13 ng/mL) was significantly higher than that in the overweight control individuals (8.9 ng/mL) (p=0.021). The acanthosis nigricans patients had significantly higher levels of insulin-like growth factor-1 in their serum samples (p=0.017). The immunohistochemical analysis determined that the skin from the acanthosis nigricans patients stained significantly more intensely for the leptin receptor compared with that seen in the skin from the patients with epidermal nevi (p=0.002).

Conclusion:
In conclusion, this study's findings suggest that the levels of leptin and insulin-like growth factor-1 in the serum, and the expression of the leptin receptor in the skin are elevated with acanthosis nigricans.
Keimyung Author(s)(Kor)
류영욱
정혜라
김성애
Publisher
School of Medicine (의과대학)
Citation
Won-Oh Kim et al. (2020). Elevated Serum Leptin Receptor and Insulin-like Growth Factor-1 Levels and High Levels of Leptin Receptor Expression in Acanthosis Nigricans Patients: Serologic and Histopathologic Analyses. 대한피부과학회지, 58(8), 530–536.
Type
Article
ISSN
2713-7627
Source
http://kjd.derma.or.kr/html/?pmode=journalview&by=2020&bm=10&vol=58&no=8&subno=&page1=530&page2=536
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42910
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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