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Pragmatic trial comparing routine versus no routine functional testing in high-risk patients who underwent percutaneous coronary intervention: Rationale and design of POST-PCI trial

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Author(s)
Yong-Hoon YoonJung-Min AhnDo-Yoon KangHanbit ParkSang-Cheol ChoPil Hyung LeeSeung-Ho HurWon-Jang KimChul Soo ParkBong-Ki LeeJung-Won SuhJung Han YoonJae Woong ChoiKi-Sik KimSi Wan ChoiSu Nam LeeSeung-Jung ParkDuk-Woo Park
Keimyung Author(s)
Hur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
American Heart Journal
Issued Date
2020
Volume
224
Abstract
Background:
Although the need to detect restenosis has diminished in the contemporary practice of percutaneous coronary intervention (PCI) with drug-eluting stents (DES), the surveillance of ischemia owing to restenosis or disease progression deserves attention in high-risk PCI settings. It is unknown whether follow-up strategy of routine noninvasive functional testing potentially reduces the risk of major cardiovascular events in high-risk PCI patients.

Methods:
The POST-PCI study is an investigator-initiated, multicenter, prospective randomized trial comparing the effectiveness of two follow-up strategies in patients with high-risk anatomic or clinical characteristics who underwent PCI. Study participants were randomly assigned to either (1) the routine noninvasive stress testing (exercise electrocardiography, nuclear stress imaging, or stress echocardiography) at 12 months post-PCI or (2) the standard-care without routine testing. In the routine stress testing group, depending on the testing results, all clinical decisions regarding subsequent diagnostic or therapeutic procedures were at the treating physician's discretion. The primary endpoint was a composite outcome of death from any causes, myocardial infarction, or hospitalization for unstable angina at 2 years post-PCI.

Results:
More than 1700 high-risk PCI patients have been randomized over 2.0 years at 11 major cardiac centers in Korea.

Conclusion:
This pragmatic POST-PCI trial will provide valuable clinical evidence on the effectiveness of follow-up strategy of routine noninvasive stress testing in high-risk PCI patients.
Keimyung Author(s)(Kor)
허승호
Publisher
School of Medicine (의과대학)
Citation
Yong-Hoon Yoon et al. (2020). Pragmatic trial comparing routine versus no routine functional testing in high-risk patients who underwent percutaneous coronary intervention: Rationale and design of POST-PCI trial. American Heart Journal, 224, 156–165. doi: 10.1016/j.ahj.2020.03.019
Type
Article
ISSN
1097-6744
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S000287032030096X
DOI
10.1016/j.ahj.2020.03.019
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42943
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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