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The Prognostic Significance of TERT Locus Polymorphism (rs36115365) in Surgically Resected Non-Small Cell Lung Cancer

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Author(s)
Deok Heon LeeSoo-Jung JungWon-Jin ParkYu-Ran HeoJae-Ho Lee
Keimyung Author(s)
Lee, Jae Ho
Department
Dept. of Anatomy (해부학)
Journal Title
Annals of clinical and laboratory science
Issued Date
2020
Volume
50
Issue
5
Keyword
rs36115365 polymorphismnon-small cell lung cancerTERT-CLPTM1L locustelomere length
Abstract
Objective:
Telomere length is an important factor for the development of non-small cell lung cancer(NSCLC), and current articles focused on telomere associated genes. We studied the clinicopathological and prognostic implications of rs36115365 polymorphism of the TERT-CLPTM1L locus in NSCLC. The association between rs36115365 and telomere length was investigated in 176 NSCLCs.

Methods:
DNA was extracted from NSCLC tissues and polymorphism and telomere length were analyzed.

Results:
The rs36115365 polymorphism showed the following frequencies according to the genotype: G/G in 81.8% of the patients, G/C in 14.2%, and C/C in 4.0%. Average telomere length in the tumor tissues were 3.06-fold longer than telomeres in paired non-tumor tissues (SD=1.87), and telomere length was not significantly different according to rs36115365 (p=0.134). The rs36115365 polymorphism did not have any relationships with clinicopathological characteristics. A poor overall survival result was found in NSCLC with Callele carriers than that with G/G allele (p=0.034). However, disease free survival rate was not different statistically (p=0.938).

Conclusions:
These findings suggest that rs36115365 may contribute to the progression of NSCLC.
Keimyung Author(s)(Kor)
이재호
Publisher
School of Medicine (의과대학)
Citation
Deok Heon Lee et al. (2020). The Prognostic Significance of TERT Locus Polymorphism (rs36115365) in Surgically Resected Non-Small Cell Lung Cancer. Annals of clinical and laboratory science, 50(5), 645–649.
Type
Article
ISSN
1550-8080
Source
http://search.ebscohost.com/login.aspx?direct=true&db=mdc&AN=33067210&site=ehost-live
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42949
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
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