계명대학교 의학도서관 Repository

Liver Resection Versus Local Ablation Therapies for Hepatocellular Carcinoma Within the Milan Criteria: A Systemic Review and Meta-analysis

Metadata Downloads
Author(s)
Seong Wook ShinKeun Soo AhnSang Woo KimTae-Seok KimYong Hoon KimKoo Jeong Kang
Keimyung Author(s)
Ahn, Keun SooKim, Tae SeokKim, Yong HoonKang, Koo Jeong
Department
Dept. of Surgery (외과학)
Journal Title
Annals of surgery
Issued Date
2021
Volume
273
Issue
4
Keyword
complicationhepatocellular carcinomaoverall survivalradiofrequency ablationrecurrenceresection
Abstract
Objective:
To compare the oncologic outcomes of liver resection (LR) and local ablation therapies for HCC.
Summary of background data: Although several studies have compared LR and local ablation therapies, the optimal treatment of choice for HCC within the Milan criteria remains controversial.

Methods:
We systemically searched the MEDLINE, Embase, and Cochrane Library databases for randomized control trials (RCTs) and matched nonrandomized trials (NRTs) that compared LR and local ablation therapies for HCC within the Milan criteria. The primary outcome was overall survival (OS). Secondary outcomes were recurrence free survival (RFS) and recurrence pattern.

Results:
A total of 7 RCTs and 18 matched NRTs, involving 2865 patients in the LR group and 2764 patients in the local ablation therapy group [RFA, MWA, RFA plus trans-arterial chemoembolization (TACE)], were included. Although there was no significant difference in OS between LR and RFA, LR showed a significantly better 5-year RFS than RFA in the analysis of RCTs (hazards ratio: 0.75; 95% confidence interval: 0.62-0.92; P = 0.006). The RFA group showed a significantly higher local recurrence than the LR group in both analyses of RCTs and NRTs. Additionally, the LR group showed better OS and RFS than the MWA or RFA plus TACE groups.

Conclusion:
Our meta-analysis showed that LR was superior to RFA in terms of RFS and incidence of local recurrence. Moreover, LR showed better oncologic outcomes than MWA or RFA plus TACE.
Keimyung Author(s)(Kor)
안근수
김태석
김용훈
강구정
Publisher
School of Medicine (의과대학)
Citation
Seong Wook Shin et al. (2021). Liver Resection Versus Local Ablation Therapies for Hepatocellular Carcinoma Within the Milan Criteria: A Systemic Review and Meta-analysis. Annals of surgery, 273(4), 656–666. doi: 10.1097/SLA.0000000000004350
Type
Article
ISSN
1528-1140
Source
https://oce.ovid.com/article/00000658-202104000-00008/HTML
DOI
10.1097/SLA.0000000000004350
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42953
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.