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Treatment strategy and outcomes in locally advanced head and neck squamous cell carcinoma: a nationwide retrospective cohort study (KCSG HN13-01)

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Author(s)
Yun-Gyoo LeeEun Joo KangBhumsuk KeamJin-Hyuk ChoiJin-Soo KimKeon Uk ParkKyoung Eun LeeJung Hye KwonKeun-Wook LeeMin Kyoung KimHee Kyung AhnSeong Hoon ShinHye Ryun KimSung-Bae KimHwan Jung Yun
Keimyung Author(s)
Park, Keon Uk
Department
Dept. of Internal Medicine (내과학)
Journal Title
BMC cancer
Issued Date
2020
Volume
20
Issue
1
Keyword
Locally advanced head and neck cancerSquamous cell carcinomaMultidisciplinary treatmentStrategy
Abstract
Background:
By investigating treatment patterns and outcomes in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), we aimed at providing valuable insights into the optimal therapeutic strategy for physicians in real-world practice.

Methods:
This is a multi-institutional study enrolled the patients with stage III to IVB LA-HNSCC, except for nasopharyngeal carcinoma, from 2004 to 2015 in thirteen referral hospitals capable of multidisciplinary care.

Results:
A total of 445 LA-HNSCC patients were analyzed. The median age was 61 years (range, 24–89). The primary tumor location was the oropharynx in 191 (43%), oral cavity in 106 (24%), hypopharynx in 64 (14%), larynx in 57 (13%) and other sites in 27 (6%). The most common stage was T2 in 172 (39%), and N2 in 245 (55%). Based on treatment intents, 229 (52%) of the patients received definitive concurrent chemoradiotherapy (CCRT) and 187 (42%) underwent surgery. Approximately 158 (36%) of the study population received induction chemotherapy (IC). Taken together, 385 (87%) of the patients underwent combined therapeutic modalities. The regimen for definitive CCRT was weekly cisplatin in 58%, 3-weekly cisplatin in 28% and cetuximab in 3%. The preferred regimen for IC was docetaxel with cisplatin in 49%, and docetaxel, cisplatin plus fluorouracil in 27%. With a median follow-up of 39 months, one-year and two-year survival rates were 89 and 80%, respectively. Overall survival was not significantly different between CCRT and surgery group (p = 0.620).

Conclusions:
In patients with LA-HNSCC, the majority of patients received combined therapeutic modalities. Definitive CCRT, IC then definitive CCRT, and surgery followed by adjuvant CCRT or radiotherapy are the preferred multidisciplinary strategies in real-world practice.
Keimyung Author(s)(Kor)
박건욱
Publisher
School of Medicine (의과대학)
Citation
Yun-Gyoo Lee et al. (2020). Treatment strategy and outcomes in locally advanced head and neck squamous cell carcinoma: a nationwide retrospective cohort study (KCSG HN13-01). BMC cancer, 20(1), 813. doi: 10.1186/s12885-020-07297-z
Type
Article
ISSN
1471-2407
Source
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-020-07297-z
DOI
10.1186/s12885-020-07297-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42972
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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