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Biobanking for glomerular diseases: a study design and protocol for KOrea Renal biobank NEtwoRk System TOward NExt-generation analysis (KORNERSTONE)

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Author(s)
Eunjeong KangYaerim KimYong Chul KimEunyoung KimNankyoung LeeYeonghui KimSoojin LeeSeungyeup HanMisun ChoeJin Ho HwangSunhwa LeeJi In ParkJung Tak ParkBeom Jin LimJung Pyo LeeJung Nam AnDong-Ryeol RyuJung-Hyun KimHee Gyung KangHyun Soon LeeKyung Chul MoonKwon Wook JooKook-Hwan OhSeung Seok HanHajeong LeeDong Ki Kim
Keimyung Author(s)
Kim, Yae RimHan, Seung YeupChoe, Mi Sun
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Journal Title
BMC nephrology
Issued Date
2020
Volume
21
Issue
1
Keyword
NephrologyPathologyGlomerulonephritis
Abstract
Backgrounds:
Glomerular diseases, a set of debilitating and complex disease entities, are related to mortality and morbidity. To gain insight into pathophysiology and novel treatment targets of glomerular disease, various types of biospecimens linked to deep clinical phenotyping including clinical information, digital pathology, and well-defined outcomes are required. We provide the rationale and design of the KOrea Renal biobank NEtwoRk System TOward Next-generation analysis (KORNERSTONE).

Methods:
The KORNERSTONE, which has been initiated by Korea Centres for Disease Control and Prevention, is designed as a multi-centre, prospective cohort study and biobank for glomerular diseases. Clinical data, questionnaires will be collected at the time of kidney biopsy and subsequently every 1 year after kidney biopsy. All of the clinical data will be extracted from the electrical health record and automatically uploaded to the web-based database. High-quality digital pathologies are obtained and connected in the database. Various types of biospecimens are collected at baseline and during follow-up: serum, urine, buffy coat, stool, glomerular complementary DNA (cDNA), tubulointerstitial cDNA. All data and biospecimens are processed and stored in a standardised manner. The primary outcomes are mortality and end-stage renal disease. The secondary outcomes will be deterioration renal function, remission of proteinuria, cardiovascular events and quality of life.

Discussion:
Ethical approval has been obtained from the institutional review board of each participating centre and ethics oversight committee. The KORNERSTONE is designed to deliver pioneer insights into glomerular diseases. The study design allows comprehensive, integrated and high-quality data collection on baseline laboratory findings, clinical outcomes including administrative data and digital pathologic images. This may provide various biospecimens and information to many researchers, establish the rationale for future more individualised treatment strategies for glomerular diseases.
Keimyung Author(s)(Kor)
김예림
한승엽
최미선
Publisher
School of Medicine (의과대학)
Citation
Eunjeong Kang et al. (2020). Biobanking for glomerular diseases: a study design and protocol for KOrea Renal biobank NEtwoRk System TOward NExt-generation analysis (KORNERSTONE). BMC nephrology, 21(1), 367. doi: 10.1186/s12882-020-02016-z
Type
Article
ISSN
1471-2369
Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-020-02016-z
DOI
10.1186/s12882-020-02016-z
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42975
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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