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Glomerular Hyperfiltration and Cancer: A Nationwide Population-Based Study

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Author(s)
Yaerim KimSoojin LeeYeonhee LeeMin Woo KangSehoon ParkSanghyun ParkKyungdo HanJin Hyuk PaekWoo Yeong ParkKyubok JinSeungyeup HanSeung Seok HanHajeong LeeJung Pyo LeeKwon Wook JooChun Soo LimYon Su KimDong Ki Kim
Keimyung Author(s)
Kim, Yae RimPark, Woo YoungJin, Kyu BokHan, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Issued Date
2020
Volume
29
Issue
10
Abstract
Background:
Glomerular hyperfiltration is associated with all-cause mortality. Herein, we evaluated the association between glomerular hyperfiltration and the development of cancer, the most common cause of death, in an Asian population.

Methods:
We retrospectively reviewed the National Health Insurance Service database of Korea for people who received national health screenings from 2012 to 2013. Glomerular hyperfiltration was defined as the 95th percentile and greater after stratification by sex and age decile. We performed a multivariate Cox regression analysis using glomerular hyperfiltration at the first health screening as the exposure variable and cancer development as the outcome variable to evaluate the impact of glomerular hyperfiltration on the development of cancer.

Results:
A total of 1,953,123 examinations for patients with a median follow-up time of 4.4 years were included in this study. Among the 8 different site-specific cancer categories, digestive organs showed significant associations between glomerular hyperfiltration and cancer. The population with glomerular hyperfiltration showed an increased risk for stomach cancer [adjusted hazard ratio (aHR) = 1.22], colorectal cancer (aHR = 1.16), and liver or intrahepatic malignancy (aHR = 1.35).

Conclusions:
Glomerular hyperfiltration was associated with an increased risk for the development of cancer in specific organs, such as the stomach, colorectum, and liver and intrahepatic organ.

Impact:
Glomerular hyperfiltration needs to be considered a significant sign of the need to evaluate the possibility of hidden adverse health conditions, including malignancies.
Keimyung Author(s)(Kor)
김예림
박우영
진규복
한승엽
Publisher
School of Medicine (의과대학)
Citation
Yaerim Kim et al. (2020). Glomerular Hyperfiltration and Cancer: A Nationwide Population-Based Study. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 29(10), 2070–2077. doi: 10.1158/1055-9965.EPI-20-0078
Type
Article
ISSN
1538-7755
Source
https://cebp.aacrjournals.org/content/29/10/2070
DOI
10.1158/1055-9965.EPI-20-0078
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42996
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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