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Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma

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Author(s)
Hyun ChangYun-Gyoo LeeYoon Ho KoJang Ho ChoJong-Kwon ChoiKeon Uk ParkEun Joo KangKeun-Wook LeeSun Min LimJin-Soo KimHyun Woo LeeMin Kyoung KimIn Gyu HwangSangwoo KimByung-Ho NamHye Ryun Kim
Keimyung Author(s)
Park, Keon Uk
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cancers
Issued Date
2020
Volume
12
Issue
7
Keyword
CD2000R1mRNA expressionprognosisimmune cellhead and neck cancer
Abstract
Immune system dysfunction is associated with head and neck squamous cell carcinoma (HNSCC) development and progression and immune checkpoint inhibitors have demonstrated substantial survival benefits in platinum-refractory HNSCC; therefore, we examined the prognostic value of immune-related gene (IRG) expression in HNSCC. We analyzed the expression of 82 IRGs in 71 patients with HNSCC enrolled in a feasibility study for a prospective HNSCC biomarker-driven umbrella trial (Korean Cancer Study Group TRIUMPH study, NCT03292250). CD200R1 was identified as an independent prognostic factor and validated in GEO and TCGA database. CD2000R1 mRNA expression was found to be an independent favorable prognostic factor in patients with HNSCC. Moreover, CD200R1 was found to affect genes and pathways associated with the immune response, while seven differentially expressed genes (CD8A, DOK2, CX3CR1, TYROBP, CXCL9, CD300LF, IFNG) were associated with CD200R1 expression. Samples with higher CD200R1 expression displayed higher tumor-infiltrating immune cell counts both in silico and in histological analysis. These findings will help in the development of more accurate prognostic tools and suggest CD200R1 modulation as a HNSCC immunotherapy.
Keimyung Author(s)(Kor)
박건욱
Publisher
School of Medicine (의과대학)
Citation
Hyun Chang et al. (2020). Prognostic Value of CD200R1 mRNA Expression in Head and Neck Squamous Cell Carcinoma. Cancers, 12(7), 1777. doi: 10.3390/cancers12071777
Type
Article
ISSN
2072-6694
Source
https://www.mdpi.com/2072-6694/12/7/1777
DOI
10.3390/cancers12071777
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43004
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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