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N-terminal pro-B-type natriuretic peptide levels in children: comparison in cardiac and non-cardiac diseases

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Author(s)
Hyun Su KimHee Joung Choi
Keimyung Author(s)
Choi, Hee Joung
Department
Dept. of Pediatrics (소아청소년학)
Journal Title
Cardiology in the young
Issued Date
2020
Volume
30
Issue
4
Abstract
Background:
N-terminal pro-B-type natriuretic peptide (NT-proBNP), a well-known marker of cardiac disease, may be elevated in acute infections and other non-cardiac diseases. The aim of this study was to evaluate NT-proBNP levels in cardiac and non-cardiac diseases and found out the patient's clinical status that affects the NT-proBNP levels.

Methods:
NT-proBNP levels were measured in three groups of children: a cardiac disease group, an infectious disease group, and a non-cardiac, non-infectious disease group.

Result:
In total, 348 children were enrolled, including 134 patients (38.5%) with cardiac disease, 170 patients (48.9%) with infectious disease, and 44 patients (12.6%) with non-cardiac, non-infectious disease. The NT-proBNP level of the cardiac disease group (median: 548 pg/mL; range: 5–35,000 pg/mL) was significantly higher than that of the infectious disease group (median: 193 pg/mL; range: 10–35,000 pg/mL) and the non-cardiac, non-infectious disease group (median: 280 pg/mL; range: 6–35,000 pg/mL). Regarding clinical status, the NT-proBNP levels were significantly higher in patients who needed mechanical ventilation support, oxygen therapy, or inotropic medication or had a change in mental status than in other patients. However, the systemic inflammatory response syndrome and mortality were not related to the NT-proBNP level.

Conclusion:
Among heterogeneous group of children, NT-proBNP level can be a useful marker of cardiac disease. Furthermore, the NT-proBNP levels were related to patients' clinical deteriorations, such as shock rather than the inflammatory status of patients.
Keimyung Author(s)(Kor)
최희정
Publisher
School of Medicine (의과대학)
Citation
Hyun Su Kim and Hee Joung Choi. (2020). N-terminal pro-B-type natriuretic peptide levels in children: comparison in cardiac and non-cardiac diseases. Cardiology in the young, 30(4), 500–504. doi: 10.1017/S1047951120000402
Type
Article
ISSN
1467-1107
Source
https://www.cambridge.org/core/journals/cardiology-in-the-young/article/abs/nterminal-probtype-natriuretic-peptide-levels-in-children-comparison-in-cardiac-and-noncardiac-diseases/E7D80E0B0C9C60E56380D44CC5BBB35E#article
DOI
10.1017/S1047951120000402
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43006
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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