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Low Bone Mineral Density in Young Patients Newly Diagnosed with Inflammatory Bowel Disease

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Author(s)
Joon Seop LeeHyun Seok LeeByung Ik JangEun Soo KimSung Kook KimKyeong Ok KimYoo Jin LeeHyun Jik LeeEun Young KimYun Jin JungChang Heon YangCrohn's and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Keimyung Author(s)
Lee, Yoo JinLee, Hyun Jik
Department
Dept. of Internal Medicine (내과학)
Journal Title
Digestive diseases and sciences
Issued Date
2020
Volume
66
Issue
2
Keyword
Inflammatory bowel diseaseBone mineral densityUlcerative colitisCrohn's disease
Abstract
Background:
The prevalence and risk factors of low bone mineral density (BMD) in Asian patients newly diagnosed with inflammatory bowel disease (IBD) have not been fully suggested.

Aims:
We aimed to examine the prevalence and risk factors of low BMD in young Korean patients newly diagnosed with IBD.

Methods:
We prospectively enrolled 132 patients aged less than 50 years and newly diagnosed with IBD from six tertiary referral centers in Korea between November 2014 and April 2017. BMD was measured by dual-energy X-ray absorptiometry, and then the Z-score was determined. We defined low BMD as a Z-score ≤ − 1.0.

Results:
Of 68 patients with ulcerative colitis (UC), 22 (32.4%) had low BMD. Also, of 64 patients with Crohn's disease (CD), 24 (37.5%) showed low BMD. Results from multivariate regression analysis identified the risk factors for low BMD as a high level of alkaline phosphatase (ALP) (≥ 140 U/L) (P = 0.010) in UC patients, and being underweight (body mass index ≤ 18.5 kg/m2) (P = 0.017) in CD patients.

Conclusions:
Our study showed that about one-third of newly diagnosed IBD Asian patients had low BMD. The clinical factors associated with low BMD were a high level of ALP in UC patients, and being underweight, in CD patients. Therefore, measurements of BMD in young patients should be considered at the diagnosis of IBD.
Keimyung Author(s)(Kor)
이유진
이현직
Publisher
School of Medicine (의과대학)
Citation
Joon Seop Lee et al. (2020). Low Bone Mineral Density in Young Patients Newly Diagnosed with Inflammatory Bowel Disease. Digestive diseases and sciences, 66(2), 605–611. doi: 10.1007/s10620-020-06220-7
Type
Article
ISSN
1573-2568
Source
https://link.springer.com/article/10.1007%2Fs10620-020-06220-7
DOI
10.1007/s10620-020-06220-7
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43055
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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