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Comparison of Serum PCSK9 Levels in Subjects with Normoglycemia, Impaired Fasting Glucose, and Impaired Glucose Tolerance

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Author(s)
Eugene HanNan Hee ChoSeong-Su MoonHochan Cho
Keimyung Author(s)
Han, Eu GeneCho, Nan HeeCho, Ho Chan
Department
Dept. of Internal Medicine (내과학)
Journal Title
Endocrinology and metabolism
Issued Date
2020
Volume
35
Issue
2
Keyword
Pro-protein convertase subtilisin-kexin type 9Prediabetic stateGlucose intoleranceGlucose tolerance testMetabolic syndrome
Abstract
We investigated proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations in individuals with normoglycemia, impaired fasting glucose (IFG), and impaired glucose tolerance (IGT). This was a pilot, cross-sectional study including 92 individuals who had not been diagnosed with or treated for diabetes. We measured PCSK9 levels in three groups of subjects; namely, normoglycemia (n=57), IFG (n=21), and IGT (n=14). Individuals with IFG and IGT showed higher PCSK9 concentrations than those in the normoglycemic group, with the highest serum PCSK9 concentrations found in individuals with IGT (55.25±15.29 ng/mL for normoglycemia, 63.47±17.78 ng/mL for IFG, 72.22±15.46 ng/mL for IGT, analysis of variance P=0.001). There were no significant differences in high- or low-density lipoprotein cholesterol among groups. Serum PCSK9 levels are increased in patients with prediabetes compared to subjects with normoglycemia.
Keimyung Author(s)(Kor)
한유진
조난희
조호찬
Publisher
School of Medicine (의과대학)
Citation
Eugene Han et al. (2020). Comparison of Serum PCSK9 Levels in Subjects with Normoglycemia, Impaired Fasting Glucose, and Impaired Glucose Tolerance. Endocrinology and metabolism, 35(2), 480–483. doi: 10.3803/EnM.2020.35.2.480
Type
Article
ISSN
2093-5978
Source
https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2020.35.2.480
DOI
10.3803/EnM.2020.35.2.480
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43058
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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