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Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial

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Author(s)
Jin Won KimSae Won HanJae Yong ChoIk-Joo ChungJong Gwang KimKyung Hee LeeKeon Uk ParkSun Kyung BaekSang Cheul OhMyung Ah LeeDoyeun OhByoungyong ShimJoong Bae AhnDongbok ShinJae Won LeeYeul Hong Kim
Keimyung Author(s)
Park, Keon Uk
Department
Dept. of Internal Medicine (내과학)
Journal Title
European Journal of Cancer
Issued Date
2020
Volume
130
Keyword
Cancer-related fatigueKorean red ginsengmFOLFOX-6Colorectal cancer
Abstract
Background:
Cancer-related fatigue (CRF) is a common symptom and has a negative impact on prognosis in cancer patients. CRF could be improved by Korean red ginseng (KRG).

Patients and methods:
For this randomised and double-blinded trial, colorectal cancer patients who received mFOLFOX-6 were randomly assigned to either KRG 2000 mg/day (n = 219) or placebo (n = 219) for 16 weeks. CRF was evaluated using the mean area under the curve (AUC) change from baseline of brief fatigue inventory (BFI) as the primary endpoint. Fatigue-related quality of life, stress, and adverse events were evaluated as secondary endpoints.

Results:
In the full analysis group, KRG up to 16 weeks improved CRF by the mean AUC change from baseline of BFI compared to placebo, particularly in "Mood" and "Walking ability" ( P = 0.038, P = 0.023, respectively). In the per-protocol group, KRG led to improved CRF in the global BFI score compared with the placebo ( P = 0.019). Specifically, there were improvements in "Fatigue right now," "Mood," "Relations with others," "Walking ability," and "Enjoyment of life" at 16 weeks ( P = 0.045, P = 0.006, P = 0.028, P = 0.003, P = 0.036, respectively). In subgroups of female patients, ≥60 years old, with high compliance (≥80%) or more baseline fatigue, the beneficial effects of KRG were more enhanced than that of placebo. Although neutropenia was more frequent in KRG than placebo, the incidence of all adverse events was similar.

Conclusions:
KRG could be safely combined with mFOLFOX-6 chemotherapy in colorectal cancer patients, and reduced CRF compared with placebo.
Keimyung Author(s)(Kor)
박건욱
Publisher
School of Medicine (의과대학)
Citation
Jin Won Kim et al. (2020). Korean red ginseng for cancer-related fatigue in colorectal cancer patients with chemotherapy: A randomised phase III trial. European Journal of Cancer, 130, 51–62. doi: 10.1016/j.ejca.2020.02.018
Type
Article
ISSN
1879-0852
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0959804920300721
DOI
10.1016/j.ejca.2020.02.018
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43067
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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