계명대학교 의학도서관 Repository

The HLA-B*13:01 and the dapsone hypersensitivity syndrome in Korean and Asian populations: genotype- and meta-analyses

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Author(s)
Hye Jung ParkJung-Won ParkSae Hoon KimSo-Yun ChoiHee-Kyoo KimChang-Gyu JungMin-Suk YangDong Yoon KangMin-Kyoung ChoHyouk-Soo KwonHye-Ryun KangYong Won Lee
Keimyung Author(s)
Jung, Chang Gyu
Department
Dept. of Internal Medicine (내과학)
Journal Title
Expert Opinion on Drug Safety
Issued Date
2020
Volume
19
Issue
10
Abstract
Background:
The human leukocyte antigen (HLA)-B*13: 01 was reported as an important risk factor for dapsone hypersensitivity syndrome (DHS) in Chinese and Thai populations.

Research design and methods:
From the Korean nationwide registry, seven subjects with previous DHS were included. Their HLA allele/phenotype frequencies were compared with 8 dapsone-tolerant subjects recruited from a single institution, and general population (n = 485) in Korea. The authors also performed a meta-analysis with these data using previous Chinese and Thai studies.

Results:
Among the seven DHS subjects, 85.7% presented with the HLA-B*13: 01 allele. The HLA-C*03: 04, HLA-DRB1*12: 02 (both in linkage disequilibrium with HLA-B*13: 01), and HLA-A*02: 01 alleles were also presented in 85.7%, 71.4%, and 71.4%, respectively. Subjects with HLA-B*13: 01 were susceptible to developing DHS compared to dapsone-tolerant controls (odds ratio [OR]: 73.667) and the Korean general population (OR: 139.500). HLA-C*03: 04 (OR: 40.935), HLA-DRB*12: 02 (OR: 36.613), and HLA-A*02: 01 (OR: 5.862) showed similar results. In meta-analysis, HLA-B*13: 01 was associated with dapsone-induced hypersensitivity (overall OR: 42.692), and subgroup analyses according to the control types demonstrated similar results (OR: 43.694 and 41.866, respectively).

Conclusions:
Similar to previous Asian population studies, HLA-B*13: 01 is significantly associated with the risk of DHS in Korea. These associations may be useful for preventing DHS and improving drug safety.
Keimyung Author(s)(Kor)
정창규
Publisher
School of Medicine (의과대학)
Citation
Hye Jung Park et al. (2020). The HLA-B*13:01 and the dapsone hypersensitivity syndrome in Korean and Asian populations: genotype- and meta-analyses. Expert Opinion on Drug Safety, 19(10), 1349–1356. doi: 10.1080/14740338.2020.1796965
Type
Article
ISSN
1744-764X
Source
https://www.tandfonline.com/doi/abs/10.1080/14740338.2020.1796965
DOI
10.1080/14740338.2020.1796965
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43077
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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