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Expression of the Long Noncoding RNA GAS5 Correlates with Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

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Author(s)
Man-Hoon Han Jee Hyun LeeGyeonghwa KimEunhye LeeYu Rim LeeSe Young Jang Hye Won Lee Jae Min ChunYoung Seok Han Jun Sik Yoon Min Kyu Kang Won Kee Lee Young Oh Kweon Won Young Tak Soo Young Park Jung Gil Park Keun Hur
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
Genes
Issued Date
2020
Volume
11
Issue
5
Keyword
biomarkerliver fibrosislncRNA GAS5nonalcoholic fatty liver diseasenoncoding RNA
Abstract
Background:
Advanced liver fibrosis is the most important prognostic factor in nonalcoholic fatty liver disease (NAFLD). The long noncoding RNA (lncRNA), growth arrest-specific transcript 5 (GAS5), is associated with the inhibition of liver fibrogenesis, and its levels are decreased in cirrhotic liver.

Methods:
We analyzed 51 patients with NAFLD, the diagnosis of which was confirmed by liver biopsy. Expression of GAS5 in both the liver and plasma of the patients was analyzed using a quantitative real-time polymerase chain reaction according to the fibrosis stage.

Results:
Plasma GAS5 expression was significantly higher in patients with advanced fibrosis than in those without. As the fibrosis progressed, GAS5 expression in plasma increased, with the exception of that in cirrhotic livers. Plasma levels of GAS5 were lower in patients with cirrhosis than in those with advanced fibrosis.

Conclusion:
Elevated circulating levels of the lncRNA GAS5 are associated with the progression of liver fibrosis prior to the development of cirrhosis.
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine (의과대학)
Citation
Man-Hoon Han et al. (2020). Expression of the Long Noncoding RNA GAS5 Correlates with Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease. Genes, 11(5), 545. doi: 10.3390/genes11050545
Type
Article
ISSN
2073-4425
Source
https://www.mdpi.com/2073-4425/11/5/545
DOI
10.3390/genes11050545
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43084
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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