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Intratumoral CD103-positive tumour-infiltrating lymphocytes are associated with favourable prognosis in patients with triple-negative breast cancer

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Author(s)
Min H ParkSun Y KwonJung E ChoiGyungyub GongYoung K Bae
Keimyung Author(s)
Kwon, Sun Young
Department
Dept. of Pathology (병리학)
Journal Title
Histopathology
Issued Date
2020
Volume
77
Issue
4
Keyword
breast neoplasmsCD103prognosis
Abstract
Aims:
Cluster of differentiation 103 (CD103), a marker of tissue resident memory T cells, is expressed on subsets of CD8+ T lymphocytes. We investigated the prognostic significance of CD103+ intra-epithelial tumour-infiltrating lymphocytes (iTILs) in invasive breast cancer (IBC).

Methods and results:
Immunohistochemistry was performed for CD103, CD8 and TGF-β isoforms (1, 2 and 3) on tissue microarrays of 1187 IBC samples. CD103+ and CD8+ iTILs were present in 904 (76.2%) and 854 (74%) cases with an overall mean ± standard deviation of 38.2 ± 100.2/mm2 and 30.4 ± 89.7/mm2 , respectively. The numbers of CD103+ and CD8+ iTILs were positively correlated, and CD103+ iTILs outnumbered CD8+ iTILs in HER2-positive and triple-negative breast cancer (TNBC). CD103+ and CD8+ iTIL densities were significantly higher in tumours of histological grade 3, absence of lymphovascular invasion, high Ki-67 index, high stromal TIL density or TGF-β3 expression. High CD103+ iTIL density was associated with better disease-free survival (DFS, P = 0.007), but no significant association was observed for overall survival (OS). Subgroup analysis by cancer molecular subtype showed that CD103+ iTIL count was prognostic only for TNBC (OS, P = 0.035; DFS, P = 0.009). CD8+ iTIL density was significant for DFS, but not for OS, in the entire cohort and TNBC. In multivariate analysis, CD103+ iTIL density was an independent prognostic factor of OS (P = 0.02) and DFS (P = 0.007) in TNBC, while CD8+ iTIL density was not significant for survival.

Conclusions:
CD103 iTIL density can serve as a predictor of good prognosis in patients with TNBC.
Keimyung Author(s)(Kor)
권선영
Publisher
School of Medicine (의과대학)
Citation
Min H Park et al. (2020). Intratumoral CD103-positive tumour-infiltrating lymphocytes are associated with favourable prognosis in patients with triple-negative breast cancer. Histopathology, 77(4), 560–569. doi: 10.1111/his.14126
Type
Article
ISSN
1365-2559
Source
https://onlinelibrary.wiley.com/doi/10.1111/his.14126
DOI
10.1111/his.14126
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43092
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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