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Molecular Epidemiology of Ciprofloxacin-Resistant Escherichia coli Isolated from Community-Acquired Urinary Tract Infections in Korea

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Author(s)
Bongyoung KimMi-Ran SeoJieun KimYeonjae KimSeong-Heon WieMoran KiYong Kyun ChoSeungkwan LimJin Seo LeeKi Tae KwonHyuck LeeHee Jin CheongDae Won ParkSeong Yeol RyuMoon-Hyun ChungHyunjoo Pai
Keimyung Author(s)
Ryu, Seong Yeol
Department
Dept. of Internal Medicine (내과학)
Journal Title
Infection & chemotherapy
Issued Date
2020
Volume
52
Issue
2
Keyword
Urinary tract infectionEscherichia coliAntimicrobial resistanceMultilocus sequence typingKorea
Abstract
Background:
Escherichia coli is the predominant causative pathogen for community-acquired urinary tract infections (UTIs), and the increase in fluoroquinolone-resistant E. coli is of great concern in Korea. The objectives of this study were to investigate the genotypic characteristics and molecular epidemiology of ciprofloxacin-resistant (CIP-R) E. coli isolated from community-acquired UTIs in Korea.

Materials and methods:
E. coli samples isolated from the blood or urine were collected from patients with community-acquired acute pyelonephritis aged 15 years and more who were admitted to 12 Korean hospitals from 1st April 2010 to 29th February 2012. Phylogenetic typing, multilocus sequence typing, and molecular characterization of β-lactamase and plasmid-mediated quinolone resistance determinants were performed for CIP-R E. coli isolates.

Results:
A total of 569 E. coli isolates were collected, and 122 (21.4%) isolates were CIP-R isolates. The most prevalent sequence type (ST) was ST131 (28.7%, 35/122), followed by ST393 (14.7%, 18/122), ST1193 (13.1%, 16/122), ST38 (9.0%, 11/122), and ST405 (8.2%, 10/122). The antimicrobial resistance rates of ST131 to cefepime (22.9%, 8/35), ST38 to gentamicin (100%, 11/11), and ST405 to cefotaxime (66.7%, 6/9) were significantly higher than the resistance rates of all other STs combined. Notably, 40% (4/10) of ST405 clones produced extended-spectrum β-lactamases and were co-resistant to trimethoprim/sulfamethoxazole. aac(6')-1b-cr (20%, 7/35) and CTX-M-14 (40%, 4/10) were more frequently observed in ST131 and ST405 compared with other clones, respectively.

Conclusions:
Among the CIP-R uropathogenic E. coli isolates in this study, ST131, ST38, and ST405 were specifically associated with antimicrobial resistance.
Keimyung Author(s)(Kor)
류성열
Publisher
School of Medicine (의과대학)
Citation
Bongyoung Kim et al. (2020). Molecular Epidemiology of Ciprofloxacin-Resistant Escherichia coli Isolated from Community-Acquired Urinary Tract Infections in Korea. Infection & chemotherapy, 52(2), 194–203. doi: 10.3947/ic.2020.52.2.194
Type
Article
ISSN
2092-6448
Source
https://www.icjournal.org/DOIx.php?id=10.3947/ic.2020.52.2.194
DOI
10.3947/ic.2020.52.2.194
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43097
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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