계명대학교 의학도서관 Repository

Adherence to dabigatran and the influence of dabigatran-induced gastrointestinal discomfort in the real-world practice

Metadata Downloads
Author(s)
Jongmin HwangSo-Ryoung LeeHyoung-Seob ParkYoung Soo LeeJin Hee AhnJong-Il ChoiDong Gu ShinDae-Kyeong KimJong Sung ParkKi Won HwangTae-Joon ChaEue-Keun ChoiSeongwook Han
Keimyung Author(s)
Hwang, Jong MinPark, Hyoung SeobHan, Seong Wook
Department
Dept. of Internal Medicine (내과학)
Journal Title
International journal of cardiology
Issued Date
2021
Volume
323
Keyword
AnticoagulantAtrial fibrillationDabigatranMedication adherence
Abstract
Background:
Dabigatran-induced gastrointestinal discomfort (DGID) is an important factor influencing the adherence to dabigatran. We investigated the incidence and risk factors of DGID and its impact on the adherence and persistence to dabigatran.

Methods:
We prospectively enrolled the patients prescribed with dabigatran in 10 tertiary hospitals of the South Korea. The adherence was assessed using the percentage of the prescribed doses of the medication presumably taken by the patient (PDT by pill count). We evaluated the relationship between DGID and the baseline GI symptoms or the previous GI disease history using a questionnaire.

Results:
A total of 474 patients (mean age 67.8 ± 9.3 years, male 68.6%, and mean CHA2DS2-VASc score 2.2 ± 1.2) were enrolled. The adherence assessed by the PDT was 93.5 ± 5.5% at 1-month and 96.4 ± 8.4% at 6-months among the persistent patients. During the 6-month follow-up, 82 (18.1%) patients discontinued dabigatran, and the most common reason for dabigatran discontinuation was DGID (49, 59.8%). Sixty-eight (14.3%) patients experienced DGID, and there was no difference in the clinical factors between those with or without DGID. Among the patients who experienced DGID, 42 discontinued dabigatran (61.8%). In a multivariate analysis, DGID was the only predictor of dabigatran discontinuation and a low adherence.

Conclusion:
Overall adherence of dabigatran was excellent, but those with DGID showed low adherence and persistence. Furthermore, it was challenging to predict DGID by clinical parameters. Therefore, it is recommended to follow the patients closely to check for DGID when prescribing dabigatran.
Keimyung Author(s)(Kor)
황종민
박형섭
한성욱
Publisher
School of Medicine (의과대학)
Citation
Jongmin Hwang et al. (2021). Adherence to dabigatran and the influence of dabigatran-induced gastrointestinal discomfort in the real-world practice. International journal of cardiology, 323, 77–82. doi: 10.1016/j.ijcard.2020.08.032
Type
Article
ISSN
1874-1754
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0167527320335592
DOI
10.1016/j.ijcard.2020.08.032
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43101
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.