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Cardiovascular disease burden in adult patients with cancer: An 11-year nationwide population-based cohort study

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Author(s)
Jong-Chan YounWoo-Baek ChungJustin A. EzekowitzJung Hwa HongHyewon NamDae-Sung KyoungIn-Cheol KimAlexander R. LyonSeok-Min KangHae Ok JungKiyuk ChangYong-Seog OhHo-Joong YounSang Hong BaekHyeon Chang Kim
Keimyung Author(s)
Kim, In Cheol
Department
Dept. of Internal Medicine (내과학)
Journal Title
International journal of cardiology
Issued Date
2020
Volume
317
Keyword
CancerCardiovascular disease burdenMortalityPopulation-based cohort
Abstract
Background:
Cardiovascular disease (CVD) is an important cause of morbidity and mortality in patients with cancer. However, the real-world CVD burden of adult cancer patients has not been well established. This study aimed to evaluate the prevalence and mortality of pre-existing and new-onset CVD in patients with cancers.

Methods:
We analysed the prevalence and mortality of pre-existing and new-onset CVD in 41,034 adult patients with ten common solid cancers in a single payer system using data from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013.

Results:
When all types of cancer were included, 11.3% (n = 4647) of patients had pre-existing CVD when they were diagnosed with cancer. After excluding patients with pre-existing CVD, 15.7% of cancer patients (n = 5703) were newly diagnosed with CVD during the follow-up period (median 68 months). Both pre-existing and new-onset CVD were associated with increased risk of overall mortality and 5-year mortality. Multivariate analysis to predict all-cause mortality indicated both pre-existing and new-onset CVD, male sex, old age, prior history of diabetes or chronic kidney disease, suburban residential area, and low-income status as significant factors.

Conclusions:
Eleven percent of cancer patients had pre-existing CVD at the time of cancer diagnosis, and about 16% of cancer patients without pre-existing CVD were newly diagnosed with CVD, mostly within 5 years after the cancer diagnosis. Proper management of pre-existing CVD is necessary and pre-emptive prevention of new-onset CVD may alter treatment options and outcomes.
Keimyung Author(s)(Kor)
김인철
Publisher
School of Medicine (의과대학)
Citation
Jong-Chan Youn et al. (2020). Cardiovascular disease burden in adult patients with cancer: An 11-year nationwide population-based cohort study. International journal of cardiology, 317, 167–173. doi: 10.1016/j.ijcard.2020.04.080
Type
Article
ISSN
1874-1754
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0167527320302606
DOI
10.1016/j.ijcard.2020.04.080
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43102
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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