Cardiovascular disease burden in adult patients with cancer: An 11-year nationwide population-based cohort study
- Author(s)
- Jong-Chan Youn; Woo-Baek Chung; Justin A. Ezekowitz; Jung Hwa Hong; Hyewon Nam; Dae-Sung Kyoung; In-Cheol Kim; Alexander R. Lyon; Seok-Min Kang; Hae Ok Jung; Kiyuk Chang; Yong-Seog Oh; Ho-Joong Youn; Sang Hong Baek; Hyeon Chang Kim
- Keimyung Author(s)
- Kim, In Cheol
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- International journal of cardiology
- Issued Date
- 2020
- Volume
- 317
- Keyword
- Cancer; Cardiovascular disease burden; Mortality; Population-based cohort
- Abstract
- Background:
Cardiovascular disease (CVD) is an important cause of morbidity and mortality in patients with cancer. However, the real-world CVD burden of adult cancer patients has not been well established. This study aimed to evaluate the prevalence and mortality of pre-existing and new-onset CVD in patients with cancers.
Methods:
We analysed the prevalence and mortality of pre-existing and new-onset CVD in 41,034 adult patients with ten common solid cancers in a single payer system using data from the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013.
Results:
When all types of cancer were included, 11.3% (n = 4647) of patients had pre-existing CVD when they were diagnosed with cancer. After excluding patients with pre-existing CVD, 15.7% of cancer patients (n = 5703) were newly diagnosed with CVD during the follow-up period (median 68 months). Both pre-existing and new-onset CVD were associated with increased risk of overall mortality and 5-year mortality. Multivariate analysis to predict all-cause mortality indicated both pre-existing and new-onset CVD, male sex, old age, prior history of diabetes or chronic kidney disease, suburban residential area, and low-income status as significant factors.
Conclusions:
Eleven percent of cancer patients had pre-existing CVD at the time of cancer diagnosis, and about 16% of cancer patients without pre-existing CVD were newly diagnosed with CVD, mostly within 5 years after the cancer diagnosis. Proper management of pre-existing CVD is necessary and pre-emptive prevention of new-onset CVD may alter treatment options and outcomes.
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