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Autologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study

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Author(s)
Jongheon JungYoon Seok ChoiJae Hoon LeeWon Sik LeeSung-hyun KimYong ParkSeung-Shin LeeYoung Rok DoJae-Cheol JoJe-Jung LeeJin Seok KimHo-Jin ShinDong-Yeop ShinSung-Soo YoonChang-Ki MinKihyun KimHyeon-Seok Eom
Keimyung Author(s)
Do, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Hematology
Issued Date
2020
Volume
112
Issue
1
Keyword
Multiple myelomaAutologousStem cellTransplantationElderly
Abstract
Autologous stem cell transplantation (ASCT) is not frequently performed for elderly patients multiple myeloma (MM) in Korea, despite its being a standardized approach for young patients. Medical records of 150 patients from 15 Korean institutions who received ASCT at age ≥ 64 years were analyzed retrospectively. Patients included had symptomatic MM, and had received their first ASCT at age ≥ 64 following induction chemotherapy. The main outcome was the response after ASCT. Overall survival (OS) and progression-free survival (PFS) were also analyzed. Median time to ASCT was 6.3 months. Complete response plus stringent complete response rate increased from 36 (24.0%) to 105 (70.0%) after ASCT, and high-quality response (≥ very good partial response) increased from 96 (64.0%) to 125 (83.3%). With a median follow-up of 32.6 months after ASCT, 5-year OS and PFS were 59.7% and 22.8%, respectively. Febrile neutropenia occurred in 43.5%, and nausea (21.3%) and stomatitis (13.2%) were common grade 3-4 non-hematologic adverse events. Of 44 deaths, disease progression (n = 23) was the most common cause of mortality, followed by infection (n = 13). Treatment-related death occurred in four cases (2.7%). ASCT is an effective and safe option for elderly MM patients and is associated with superior clinical outcomes.
Keimyung Author(s)(Kor)
도영록
Publisher
School of Medicine (의과대학)
Citation
Jongheon Jung et al. (2020). Autologous stem cell transplantation in elderly patients with multiple myeloma in Korea: the KMM1807 study. International Journal of Hematology, 112(1), 84–95. doi: 10.1007/s12185-020-02869-y
Type
Article
ISSN
1865-3774
Source
https://link.springer.com/article/10.1007%2Fs12185-020-02869-y
DOI
10.1007/s12185-020-02869-y
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43110
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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