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Prospective study on cytokine levels in medication-naïve adolescents with first-episode major depressive disorder

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Author(s)
Hojun LeeMinjae SongJongha LeeJung-Bum KimMoon-Soo Lee
Keimyung Author(s)
Lee, Ho JunKim, Jung Bum
Department
Dept. of Psychiatry (정신건강의학)
Journal Title
Journal of affective disorders
Issued Date
2020
Volume
266
Keyword
AdolescentCytokineDepressionFirst-episodeInflammationMedication-naïve
Abstract
Background:
Evidence suggests that depression is correlated with immune-inflammatory responses, and efforts have been made to identify the relationships between depression and inflammatory markers. This study investigated the level of cytokines before and after treatment for major depressive disorder (MDD) in medication-naïve adolescents with first-episode MDD and compared them with the levels in healthy adolescents. The relationship between cytokine levels and the severity of depressive symptoms was also examined.

Methods:
Twenty-five adolescents with MDD and 25 healthy controls aged 13 to 18 years were included in the study. Blood samples were obtained, and depression severity was assessed twice in the MDD group before and after treatment and once in the healthy group.

Results:
When compared with healthy controls, adolescents with MDD had lower levels of interleukin 2 (IL-2), interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α) and IL-10 before treatment and higher levels of IL-2, IFN-γ, and IL-10 after treatment. In addition, the IFN-γ levels correlated with depressive severity scores in both the Children's Depression Inventory (CDI) and Hamilton Depression Rating Scale (HDRS). The IL-10 level correlated with depressive severity only on the HDRS.

Limitations:
The sample size was small, and the 12-week follow-up time after treatment was relatively short.

Conclusion:
IL-2, IFN-γ, TNF-α, and IL-10 levels in medication-naïve adolescents with first-episode MDD differed from those in healthy controls. The levels of IL-2, IFN-γ, and IL-10 were altered after antidepressant treatment. Further, the IFN-γ and IL-10 levels correlated with the severity of depressive symptoms.
Keimyung Author(s)(Kor)
이호준
김정범
Publisher
School of Medicine (의과대학)
Citation
Hojun Lee et al. (2020). Prospective study on cytokine levels in medication-naïve adolescents with first-episode major depressive disorder. Journal of affective disorders, 266, 57–62. doi: 10.1016/j.jad.2020.01.125
Type
Article
ISSN
1573-2517
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0165032719326850
DOI
10.1016/j.jad.2020.01.125
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43123
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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