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Sex Differences in Long-Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation

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Author(s)
Masahiro HoshinoRikuta HamayaYoshihisa KanajiYoshinori KannoMasahiro HadaMasao YamaguchiYohei SuminoHidenori HiranoTomoki HorieEisuke UsuiTomoyo SugiyamaTadashi MuraiTetsumin LeeTaishi YonetsuJoo Myung LeeKi Hong ChoiDoyeon HwangJonghanne ParkJi‐Hyun JungHyung Yoon KimHae Won JungYun‐Kyeong ChoHyuck‐Jun YoonYoung Bin SongJoo‐Yong HahnJoon‐Hyung DohChang‐Wook NamEun‐Seok ShinSeung‐Ho HurHernán Mejía‐RenteríaFrancesco LauriSonoka GotoFernando MacayaAngela McInerneyGiacomo GravinaRafael VeraNieves GonzaloPilar Jimenez‐QuevedoIvan Nuñez‐GilPablo SalinasLuis Nombela‐FrancoMaria del TrigoAntonio Fernández‐OrtizCarlos MacayaBon‐Kwon KooJavier EscanedTsunekazu Kakuta
Keimyung Author(s)
Cho, Yun KyeongYoon, Hyuck JunNam, Chang WookHur, Seung Ho
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of the American Heart Association
Issued Date
2020
Volume
9
Issue
4
Keyword
coronary flow reservefractional flow reservemicrovascular dysfunctionsex differences
Abstract
Background:
Sex-specific differences may influence prognosis after deferred revascularization following fractional flow reserve (FFR) measurement. This study sought to investigate the sex differences in long-term prognosis of patients with deferred revascularization following FFR assessment.

Methods and Results:
A total of 879 patients (879 vessels) with deferred revascularization with FFR >0.75 who underwent FFR and coronary flow reserve measurements were enrolled from 3 countries (Korea, Japan, and Spain). Long-term outcomes were assessed in 649 men and 230 women by the patient-oriented composite outcome (POCO, a composite of any death, any myocardial infarction, and any revascularization). We applied inverse-probability weighting based on propensity scores to account for differences at baseline between women and men (age, hyperlipidemia, diabetes mellitus, diameter stenosis, lesion length, multivessel disease, FFR, coronary flow reserve. The median follow-up duration was 1855 days (745-1855 days). Median FFR values were 0.88 (0.83-0.93) in men and 0.89 (0.85-0.94) in women, respectively. The occurrences of POCO were significantly high in men compared with that in women (10.5% versus 4.2%, P=0.007). Kaplan-Meier analysis revealed that women had a significantly lower risk of POCO (χ2=7.2, P=0.007). Multivariate COX proportional hazards regression analysis revealed that age, male, diabetes mellitus, diameter stenosis, lesion length, and coronary flow reserve were independent predictors of POCO. After applying IPW, the hazard ratio of males for POCO was 2.07 (95% CI, 1.07-4.04, P=0.032).

Conclusions:
This large multinational study reveals that long-term outcome differs between women and men in favor of women after FFR-guided revascularization deferral.
Keimyung Author(s)(Kor)
조윤경
윤혁준
남창욱
허승호
Publisher
School of Medicine (의과대학)
Citation
Masahiro Hoshino et al. (2020). Sex Differences in Long-Term Outcomes in Patients With Deferred Revascularization Following Fractional Flow Reserve Assessment: International Collaboration Registry of Comprehensive Physiologic Evaluation. Journal of the American Heart Association, 9(4), e014458. doi: 10.1161/JAHA.119.014458
Type
Article
ISSN
2047-9980
Source
https://www.ahajournals.org/doi/10.1161/JAHA.119.014458
DOI
10.1161/JAHA.119.014458
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43128
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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