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Impact of 6% balanced hydroxyethyl starch following cardiopulmonary bypass on renal function: a retrospective study

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Author(s)
Ju Yong LimYun Seok KimJoon Bum Kim
Keimyung Author(s)
Kim, Yun Seok
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Journal Title
Journal of Cardiothoracic Surgery
Issued Date
2020
Volume
15
Issue
1
Keyword
Hydroxyethyl starchAcute kidney injuryCardiopulmonary bypass
Abstract
Background:
We aimed to evaluate the effect of limited volume of hydroxyethyl starch (HES) administration on postoperative renal function in patients undergoing cardiac surgery under cardiopulmonary bypass (CPB).

Methods:
One thousand six hundred fifty-seven patients undergoing cardiac surgery under CPB over two years were included. The patients were divided according to the amount of HES administrated during the first 2 days post-surgery; moderate dose HES (≥20 ml/kg) versus low dose HES (< 20 ml/kg). Outcomes were compared by using inverse probability weighting.

Results:
Incidence of acute kidney injury (AKI) was higher in the moderate HES group (p = .02). However, new renal replacement therapy (RRT) (P = .30) and early mortality (p = .97) was similar between the groups. When adjusted, the moderate HES use was associated with AKI (OR, 1.66; 95% CI, 1.12-2.44; p = .01), but did not increase the risk of new RRT (OR, 1.27; 95% CI, 0.71-2.18; p = .40) or early mortality (HR, 0.73; 95% CI, 0.29-1.81; p = .50).

Conclusions:
The moderate dose administration of HES (≥20 ml/kg) in the postoperative period following cardiac surgery might be associated with the risk of AKI. However, it was not associated with serious adverse outcomes such as new RRT or mortality. Further randomized controlled studies are needed to validate study results.
Keimyung Author(s)(Kor)
김윤석
Publisher
School of Medicine (의과대학)
Citation
Ju Yong Lim et al. (2020). Impact of 6% balanced hydroxyethyl starch following cardiopulmonary bypass on renal function: a retrospective study. Journal of Cardiothoracic Surgery, 15(1), 237–243. doi: 10.1186/s13019-020-01286-w
Type
Article
ISSN
1749-8090
Source
https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-020-01286-w
DOI
10.1186/s13019-020-01286-w
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43139
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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