계명대학교 의학도서관 Repository

Optimizing Preparative Regimen for Umbilical Cord Blood Transplantation in Adult Acute Leukemia Patients: Acute Lymphoblastic Leukemia Requires Myeloablative Conditioning but Not Acute Myeloid Leukemia

Metadata Downloads
Author(s)
Ja Min ByunJunshik HongDoyeun OhHo-Young YhimYoung Rok DoJoon Seong ParkChul Won JungDeok-Hwan YangJong-Ho WonHong Ghi LeeJoon Ho MoonYeung-Chul MunDeog-Yeon JoJae Joon HanJe-Hwan LeeJae Hoon LeeJunglim LeeSung-Soo Yoon
Keimyung Author(s)
Do, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of clinical medicine
Issued Date
2020
Volume
9
Issue
7
Keyword
cord blood transplantationacute myeloid leukemiaacute lymphoblastic leukemiaconditioning
Abstract
Cord blood transplantation (CBT) is a valuable alternative to bone marrow transplantation in adults without readily available donors. We conducted this study to investigate the feasibility of CBT for adult patients with acute leukemia with regards to impact of different conditioning and graft-versus-host disease (GVHD) prophylaxis regimens on clinical outcomes. From 16 centers in Korea, 41 acute myeloid leukemia (AML) and 29 ALL (acute lymphoblastic leukemia) patients undergoing CBT were enrolled. For AML patients, the neutrophil engraftment was observed in 87.5% of reduced intensity conditioning (RIC) and 72.0% of myeloablative conditioning (MAC) (p = 0.242). The median RFS was 5 months and OS 7 months. Conditioning regimen did not affect relapse free survival (RFS) or overall survival (OS). GVHD prophylaxis using calcineurin inhibitors (CNI) plus methotrexate was associated with better RFS compared to CNI plus ATG (p = 0.032). For ALL patients, neutrophil engraftment was observed in 55.6% of RIC and 90.0% of MAC (p = 0.034). The median RFS was 5 months and OS 19 months. MAC regimens, especially total body irradiation (TBI)-based regimen, were associated with both longer RFS and OS compared to other conditioning regimens. In conclusion, individualized conditioning regimens will add value in terms of enhancing safety and efficacy of CBT.
Keimyung Author(s)(Kor)
도영록
Publisher
School of Medicine (의과대학)
Citation
Ja Min Byun et al. (2020). Optimizing Preparative Regimen for Umbilical Cord Blood Transplantation in Adult Acute Leukemia Patients: Acute Lymphoblastic Leukemia Requires Myeloablative Conditioning but Not Acute Myeloid Leukemia. Journal of clinical medicine, 9(7), 2310–2325. doi: 10.3390/jcm9072310
Type
Article
ISSN
2077-0383
Source
https://www.mdpi.com/2077-0383/9/7/2310
DOI
10.3390/jcm9072310
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43149
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.