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Symptom-related changes in current perception threshold of restless legs syndrome

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Author(s)
Hung Youl SeokSo Young DoGholam K. MotamediYong Won Cho
Keimyung Author(s)
Seok, Hung YoulCho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of sleep research
Issued Date
2020
Volume
29
Issue
3
Keyword
central sensory processing disturbancecurrent perception threshold testpathophysiologyrestless legs syndrome
Abstract
Few studies have investigated the mechanisms responsible for the symptoms of restless legs syndrome (RLS). However, these studies were mainly performed during the asymptomatic period and therefore their findings might not apply to changes in sensory processing that occur during the symptomatic period. The objective of this study was to investigate the function of sensory nerve fibres in RLS patients using the current perception threshold (CPT) test during the daytime and in the presence of symptoms. Ninety-three patients with RLS and 34 healthy controls were included in the study. RLS patients were further divided into two subgroups, those who were experiencing RLS symptoms during the CPT test (symptom+) and those without symptoms (symptom-). Demographic data, RLS rating scale score and visual analogue scale were collected. Of the 127 enrolled subjects, CPT values were significantly lower in RLS patients than in controls for all three frequencies. Among the control and RLS subgroups (53 symptom+, 40 symptom-), symptom+ patients showed lower CPT values than controls. This finding indicates a relative hyperaesthetic state in the sensory afferents of peripheral nerves in symptom+ patients. There were no significant differences between the symptom- group and controls. The significantly lower CPT values for all three frequencies in symptom+ patients suggest that central sensory processing disturbance of sensory nerve fibres' input may be involved in the development of symptoms in RLS patients.
Keimyung Author(s)(Kor)
석흥열
조용원
Publisher
School of Medicine (의과대학)
Citation
Hung Youl Seok et al. (2020). Symptom-related changes in current perception threshold of restless legs syndrome. Journal of sleep research, 29(3), e12980. doi: 10.1111/jsr.12890
Type
Article
ISSN
1365-2869
Source
https://onlinelibrary.wiley.com/doi/full/10.1111/jsr.12890
DOI
10.1111/jsr.12890
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43198
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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