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Environmental risk factors and comorbidities of primary biliary cholangitis in Korea: a case-control study

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Author(s)
Kyung-Ah KimYoung Seok Kim Sang Hoon ParkWoo Jin Chung Dae Hee Choi Eun Sun Jang Sook-Hyang Jeong 
Keimyung Author(s)
Chung, Woo Jin
Department
Dept. of Internal Medicine (내과학)
Journal Title
The Korean journal of internal medicine
Issued Date
2020
Volume
36
Issue
2
Keyword
Liver cirrhosis, biliaryRisk factorsSmokingEthanolAbortion induced
Abstract
Background/aims:
The risk factors for the development of primary biliary cholangitis (PBC) is unclear. This study aimed to investigate the risk factors associated with PBC in Korea through a questionnaire survey.

Methods:
Consecutively enrolled 103 PBC patients from six referral hospitals and 100 age- and sex-matched community controls participated in this study. A standardized questionnaire survey including demographics, lifestyle, individual and familial medical history and reproductive history was prospectively collected and analyzed.

Results:
The PBC patients had a mean age of 58.3 years and a female proportion of 86.4%. The age- and sex-matched controls had a similar educational level and economic status to the PBC patients. Among the lifestyle factors, the multivariable analysis showed smoking including both first-hand and second-hand (odds ratio [OR], 2.03; 95% confidence interval [CI], 1.06 to 3.93), history of autoimmune diseases (OR, 2.46; 95% CI, 1.06 to 6.35), and family history of PBC (OR, 17.76; 95% CI, 1.77 to 2,418.74) were significantly associated with PBC, whereas alcohol intake was negatively associated with PBC. Among reproductive factors, the number of induced abortions was significantly associated with PBC, while the number of full-term deliveries was negatively associated with PBC.

Conclusions:
A family history of PBC, accompanying autoimmune diseases, and smoking were significantly associated with PBC. More induced abortions and less full-term deliveries were associated with PBC in women. In contrast, mild to moderate alcohol intake was negatively associated with PBC. Further studies are warranted to validate the results of this study and to search for clues about the pathogenesis of PBC.
Keimyung Author(s)(Kor)
정우진
Publisher
School of Medicine (의과대학)
Citation
Kyung-Ah Kim et al. (2020). Environmental risk factors and comorbidities of primary biliary cholangitis in Korea: a case-control study. The Korean journal of internal medicine, 36(2), 313–321. doi: 10.3904/kjim.2019.234
Type
Article
ISSN
2005-6648
Source
https://www.kjim.org/journal/view.php?doi=10.3904/kjim.2019.234
DOI
10.3904/kjim.2019.234
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43223
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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