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Treatment pattern and overall survival in esophageal cancer during a 13-year period: A nationwide cohort study of 6,354 Korean patients

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Author(s)
Hye-Kyung JungChung Hyun TaeHye-Ah LeeHyuk LeeKee Don ChoiJun Chul ParkJoong Goo KwonYoon Jin ChoiSu Jin HongJaekyu SungWoo Chul ChungKi Bae KimSeung Young KimKyung Ho SongKyung Sik ParkSeong Woo JeonByung-Wook KimHan Seung RyuOk-Jae LeeGwang Ho BaikYong Sung KimHwoon-Yong Jung
Keimyung Author(s)
Park, Kyung Sik
Department
Dept. of Internal Medicine (내과학)
Journal Title
PLoS One
Issued Date
2020
Volume
15
Issue
4
Abstract
Using data from the real world to solve clinical questions that cannot be answered using data from clinical trials is attracting more attention. Clinical outcomes for patients with esophageal cancer in a real-world setting might be different from data in randomized controlled trials. This study aimed to provide real world data on treatment and prognosis in Korean patients with esophageal cancer. This retrospective cancer cohort included newly diagnosed cases of esophageal cancer at 19 tertiary hospitals between January 1, 2005 and December 31, 2017. Cancer staging was defined according to the 7th edition of the American Joint Committee on Cancer criteria. We identified 6,354 patients with newly diagnosed esophageal cancer (mean age: 64.9 ± 9.0 years, 96.9% squamous cell carcinoma). The proportion of early esophageal cancer increased from 24.7% in 2005 to 37.2% in 2015 (p<0.001). Among all cases, surgery alone was 31.3%, followed by definitive concurrent chemoradiotherapy (CCRT) (27.0%), neoadjuvant therapy (12.4%), adjuvant therapy (11.1%), and endoscopic resection (5.8%). The 5-year overall survival rate was 45.7 ± 0.7%. Endoscopic resection provided similar median survival relative to surgery for stage Ia cases. Among stage II-III cases, definitive CCRT was associated with poorer survival than neoadjuvant or adjuvant therapy, although there was no survival difference between neo-adjuvant and adjuvant therapy. Early esophageal cancer is gradually becoming more common and endoscopic resection provided similar long-term survival relative to surgery. Surgery with combined therapy provided better survival in locally advanced esophageal cancer, relative to definitive CCRT.
Keimyung Author(s)(Kor)
박경식
Publisher
School of Medicine (의과대학)
Citation
Hye-Kyung Jung et al. (2020). Treatment pattern and overall survival in esophageal cancer during a 13-year period: A nationwide cohort study of 6,354 Korean patients. PLoS One, 15(4), e0231456. doi: 10.1371/journal.pone.0231456
Type
Article
ISSN
1932-6203
Source
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231456
DOI
10.1371/journal.pone.0231456
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43281
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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