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Postoperative radiotherapy for WHO grade II-III intracranial ependymoma in adults: An intergroup collaborative study (KROG 18-06/KNOG 18-01)

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Author(s)
Chan Woo WeeIl Han KimChul-Kee ParkDo Hoon LimDo-Hyun NamHong In YoonChang-Ok SuhJong Hee ChangWoong-Ki ChungTae-Young JungShin-Hyung ParkChae-Yong KimYoung Zoon KimHo Shin GwakKwan Ho ChoJin Hee KimJung Ho ImWoo Chul KimSung-Hwan KimIn Ah Kim
Keimyung Author(s)
Kim, Jin Hee
Department
Dept. of Radiation Oncology (방사선종양학)
Journal Title
Radiotherapy and Oncology
Issued Date
2020
Volume
150
Keyword
EpendymomaAdultIntracranialRadiotherapySurvival
Abstract
Background and purpose:
To evaluate the impact of adjuvant postoperative radiotherapy (PORT) in adult WHO grade II-III intracranial ependymoma (IEPN).

Materials and methods:
A total of 172 pathologically confirmed adult grade II-III IEPN patients from 12 institutions were eligible. Of them, 106 (61.6%) and 66 (38.4%) patients were grade II and III, respectively. For grade II and III IEPNs, 51 (48.1%) and 59 (89.4%) patients received PORT, respectively. The median dose to the primary tumor bed was 54.0 Gy and 59.4 Gy for grade II and III patients, respectively. The prognostic impact of sex, age, performance, WHO grade, location, size, surgical extent, and PORT on local control (LC), progression-free survival (PFS), and overall survival (OS) were evaluated by univariate and multivariate analysis.

Results:
The median follow-up period for survivors was 88.1 months. The 5-/10-year LC, PFS, and OS rates were 64.8%/54.0%, 56.4%/44.8%, and 76.6%/71.0%, respectively. On multivariate analysis, adjuvant PORT significantly improved LC (P = 0.002), PFS (P = 0.002), and OS (P = 0.043). Older age (P < 0.001), WHO grade III (P < 0.001), larger tumor size (P = 0.004), and lesser surgical extent (P < 0.001) were also negative factors for OS. Adjuvant PORT also improved LC (P = 0.010), PFS (P = 0.007), and OS (P = 0.069) on multivariate analysis for grade II IEPNs.

Conclusion:
This multicenter retrospective study supports the role of adjuvant PORT in terms of disease control and survival in adult grade II-III IEPNs. Prospective randomized trials focused on individualized treatment based on molecular subtypes is warranted.
Keimyung Author(s)(Kor)
김진희
Publisher
School of Medicine (의과대학)
Citation
Chan Woo Wee et al. (2020). Postoperative radiotherapy for WHO grade II-III intracranial ependymoma in adults: An intergroup collaborative study (KROG 18-06/KNOG 18-01). Radiotherapy and Oncology, 150, 4–11. doi: 10.1016/j.radonc.2020.05.045
Type
Article
ISSN
1879-0887
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0167814020303017
DOI
10.1016/j.radonc.2020.05.045
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43286
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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