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Alterations in Salience Network Functional Connectivity in Individuals with Restless Legs Syndrome

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Author(s)
Jeonghun KuYeong Seon LeeKeun Tae KimHyukWon ChangYong Won Cho
Keimyung Author(s)
Ku, Jeong HunKim, Keun TaeChang, Hyuk WonCho, Yong Won
Department
Dept. of Biomedical Engineering (의용공학과)
Dept. of Neurology (신경과학)
Dept. of Radiology (영상의학)
Journal Title
Scientific Reports
Issued Date
2020
Volume
10
Issue
1
Abstract
Background and purpose:
Restless legs syndrome (RLS) is a neurological disorder which is most commonly identified by an urge to move the legs. It often shows alterations in sensory processing which implies the salience network (SN) is experiencing changes. This study investigates the functional connectivity (FC) between the SN and other areas of the brain in RLS patients during the resting state period.

Methods:
Thirty patients with drug naïve idiopathic RLS and 30 healthy age and gender matched controls were included in this study. Resting state fMRIs were performed in the morning during the asymptomatic period. The SN comparisons were conducted between the two groups.

Results:
The RLS group showed a reduction in SN FC in the right pyramis, and an increase in SN FC in the bilateral orbitofrontal gyri and right postcentral gyrus.

Conclusions:
The results of this study give reason to believe that SN FC in RLS patients is altered during asymptomatic periods. This could have an influence on the processing of the saliency of information, particularly sensory information processing and inhibition mechanisms.
Keimyung Author(s)(Kor)
구정훈
김근태
장혁원
조용원
Publisher
School of Medicine (의과대학)
Citation
Jeonghun Ku et al. (2020). Alterations in Salience Network Functional Connectivity in Individuals with Restless Legs Syndrome. Scientific Reports, 10(1), 7643. doi: 10.1038/s41598-020-64641-w
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-020-64641-w
DOI
10.1038/s41598-020-64641-w
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43292
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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