계명대학교 의학도서관 Repository

Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes

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Author(s)
Eugene HanJi-Yeon LeeKyung-do HanHanna ChoKwang Joon KimByung-Wan LeeEun Seok KangBong-Soo ChaZobair M YounossiYong-Ho Lee
Keimyung Author(s)
Han, Eu Gene
Department
Dept. of Internal Medicine (내과학)
Journal Title
Scientific Reports
Issued Date
2020
Volume
10
Issue
1
Abstract
Diabetes is associated with cognitive impairment and greater risk for dementia, but the role of gamma-glutamyltransferase (γ-GT) in dementia has not been elucidated. We determined incident dementia including Alzheimer's disease and vascular dementia, analyzing data from participants aged 40 years or older in the National Health Insurance Database, collected by the National Health Insurance Service in Korea, from January 2009 to December 2015. During a median follow-up of 7.6 years, 272,657 participants were diagnosed as having dementia. Higher serum γ-GT was associated with increased risk of dementia (HR = 1.22, 95% CI = 1.20-1.24), and had a strong positive association with early onset dementia (HR = 1.32, 95% CI = 1.24-1.40). An additive impact of higher γ-GT on dementia was observed regardless of glycemic status, and prevalent diabetes with the highest γ-GT quartile had a 1.8-fold increased dementia risk (HR = 1.82, 95% CI = 1.78-1.85). This effect of γ-GT concentration in diabetes was more prominent in individuals with vascular dementia (HR = 1.94, 95% CI = 1.84-2.04). In subgroup analysis, young age, male sex, and relatively healthy subjects with a higher γ-GT quartile had more increased dementia risk. In conclusion, γ-GT concentration as well as glycemic status could be a future risk factor for dementia in the general population.
Keimyung Author(s)(Kor)
한유진
Publisher
School of Medicine (의과대학)
Citation
Eugene Han et al. (2020). Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes. Scientific Reports, 10(1), 6800. doi: 10.1038/s41598-020-63803-0
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-020-63803-0
DOI
10.1038/s41598-020-63803-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43295
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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