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Impact of acute kidney injury in elderly versus young deceased donors on post-transplant outcomes: A multicenter cohort study

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Author(s)
Woo Yeong ParkJeong Ho KimEun Jung KoJi-Won MinTae Hyun BanHye-Eun YoonYoung Soo KimKyubok JinSeungyeup HanChul Woo YangByung Ha Chung
Keimyung Author(s)
Jin, Kyu BokHan, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Scientific Reports
Issued Date
2020
Volume
10
Issue
1
Abstract
We investigated the impact of acute kidney injury (AKI) in elderly deceased-donors (DDs) vs. AKI in young DDs on post-transplant clinical outcomes. A total of 709 kidney transplant recipients (KTRs) from 602 DDs at four transplant centers were enrolled. KTRs were divided into young-DDKT and elderly-DDKT groups according to the age of DD of 60 years. Both groups were subdivided into non-AKI-KT and AKI-KT subgroups according to AKI in DDs. We investigated short-term and long-term clinical outcomes of non-AKI-DDKT and AKI-DDKT subgroups within young-DDKT and elderly-DDKT groups. The incidence of DGF in the AKI-DDKT subgroup was higher and the allograft function within 12 months after KT in the AKI-DDKT subgroup was lower than those in the non-AKI-DDKT subgroup in both young-DDKT and elderly-DDKT groups. Death-censored allograft survival rate was significantly lower in the AKI-elderly-DDKT subgroup than that in the non-AKI-elderly-DDKT subgroup, but it did not differ between AKI-young-DDKT and non-AKI-young-DDKT subgroup. In multivariable analysis, AKI-elderly-DDKT was an independent risk factor for allograft failure (hazard ratio: 2.648, 95% CI: 1.170-5.994, p = 0.019) and a significant interaction between AKI and old age in DDs on allograft failure was observed (p = 0.001). AKI in elderly DDs, but not in young DDs, can significantly affect long-term allograft outcomes of KTRs.
Keimyung Author(s)(Kor)
진규복
한승엽
Publisher
School of Medicine (의과대학)
Citation
Woo Yeong Park et al. (2020). Impact of acute kidney injury in elderly versus young deceased donors on post-transplant outcomes: A multicenter cohort study. Scientific Reports, 10(1), 3727. doi: 10.1038/s41598-020-60726-8
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-020-60726-8
DOI
10.1038/s41598-020-60726-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43297
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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