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Retinal vascular development in an immature retina at 33-34 weeks postmenstrual age predicts retinopathy of prematurity

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Author(s)
Ji Hye Jang Yu Cheol Kim
Keimyung Author(s)
Jang, Ji HyeKim, Yu Cheol
Department
Dept. of Ophthalmology (안과학)
Journal Title
Scientific Reports
Issued Date
2020
Volume
10
Issue
1
Abstract
In preterm birth, the immature retina can develop a potentially blinding disorder of the eye known as retinopathy of prematurity (ROP). The vaso-proliferative phase of ROP begins at an approximate postmenstrual age (PMA) of 32 weeks. There is little or no evidence of an association between ROP development and retinal status in the early vaso-proliferative phase. We aimed to evaluate the retinal vascular findings of infants at 33-34 weeks PMA to determine their risk of ROP. We reviewed 130 serial wide-field retinal images from 65 preterm infants born before the gestational age of 31 weeks. ROP occurred more frequently in infants having a leading vascular edge within posterior Zone II. This was in contrast to normal infants, who are characterized by complete retinal vascularization up to Zone II at 34 weeks PMA. The probability of ROP development in preterm infants with retinal edge hemorrhage was 24.58 times higher than in preterm infants without retinal edge hemorrhage. Eyes with ROP that required treatment showed significantly delayed retinal vascularization accompanied by pre-plus disease. In conclusion, retinal status in the early vaso-proliferation phase might determine the risk of ROP.
Keimyung Author(s)(Kor)
장지혜
김유철
Publisher
School of Medicine (의과대학)
Citation
Ji Hye Jang and  Yu Cheol Kim. (2020). Retinal vascular development in an immature retina at 33-34 weeks postmenstrual age predicts retinopathy of prematurity. Scientific Reports, 10(1), 18111. doi: 10.1038/s41598-020-75151-0
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-020-75151-0
DOI
10.1038/s41598-020-75151-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43302
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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