계명대학교 의학도서관 Repository

Usefulness of diffusion tensor imaging findings as biomarkers for amyotrophic lateral sclerosis

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Author(s)
Seol-Hee BaekJinseok ParkYoo Hwan KimHung Youl SeokKi-Wook OhHee-Jin KimYe-Ji KwonYoungbo SimWoo-Suk TaeSeung Hyun KimByung-Jo Kim
Keimyung Author(s)
Seok, Hung Youl
Department
Dept. of Neurology (신경과학)
Journal Title
Scientific Reports
Issued Date
2020
Volume
10
Issue
1
Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. However, no reliable biomarkers have been identified to represent the clinical status. This study aimed to investigate whether diffusion tensor imaging (DTI) findings are useful imaging biomarkers to indicate the clinical status of ALS patients. Ninety-six probable or definite ALS cases and 47 age- and sex-matched, normal controls were enrolled. Demographic and clinical data were collected at the time of DTI. DTI data were acquired using a 3-Tesla magnetic resonance imaging scanner and analysed by voxel-wise statistical analyses for fractional anisotropy, axial diffusivity, radial diffusivity, mean diffusivity, and mode of anisotropy. Compared with the healthy control group, the ALS group had significant differences in DTI scalars in the diffuse tracts of the brain, which was predominant in the corticospinal tract at the brainstem and cerebellar peduncle area. Furthermore, the DTI values correlated with the ALS functional rating scale-revised (ALSFRS-R) scores and the delta ALSFRS-R score representing the rate of disease progression. The subgroup analysis revealed a more severe and widespread brain degeneration was observed in rapidly progressive ALS. Therefore, our results suggest that DTI findings are useful as imaging biomarkers for evaluating the clinical severity and rate of disease progression in ALS.
Keimyung Author(s)(Kor)
석흥열
Publisher
School of Medicine (의과대학)
Citation
Seol-Hee Baek et al. (2020). Usefulness of diffusion tensor imaging findings as biomarkers for amyotrophic lateral sclerosis. Scientific Reports, 10(1), 5199. doi: 10.1038/s41598-020-62049-0
Type
Article
ISSN
2045-2322
Source
https://www.nature.com/articles/s41598-020-62049-0
DOI
10.1038/s41598-020-62049-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43305
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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