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Resting-state connectivity and the effects of treatment in restless legs syndrome

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Author(s)
Yeong Seon Lee Jeonghun Ku Keun Tae Kim HyukWon Chang Christopher J Earley Richard P Allen Yong Won Cho
Keimyung Author(s)
Kim, Keun TaeChang, Hyuk WonCho, Yong Won
Department
Dept. of Neurology (신경과학)
Dept. of Radiology (영상의학)
Journal Title
Sleep Medicine
Issued Date
2020
Volume
67
Keyword
Restless legs syndromeResting state fMRIDopamineTreatment
Abstract
Objectives:
Resting-state brain connectivity has been shown to differ for Restless Legs Syndrome (RLS) compared to healthy control (CON) groups. This study evaluates the degree these RLS-CON differences are changed by concurrent treatment.

Methods:
Resting-state functional MRIs were obtained from 32 idiopathic RLS patients during the morning asymptomatic period and 16 age and gender-matched CON subjects. Of the 32 RLS patients, 16 were drug-naïve (DN-RLS), and 16 were regularly drug-treated using a dopamine agonist (DT-RLS). Various assessments of disease characteristics were also performed. The primary purpose was to assess the replicability of prior results and the effects of treatment on these differences between controls and untreated RLS patients. Resting-state connectivity was analyzed by a seed-based method using the bilateral ventral-posterolateral nuclei (VPLN) in the thalamus.

Results:
In the DN-RLS group, compared to the CON group, three areas (the bilateral lingual gyri and right middle temporal gyrus) were replicated. The three replicated areas did not significantly differ for DT-RLS compared to DN-RLS. DT-RLS compared to DN-RLS had significantly higher thalamic connectivity for the left uvula, right tuber, left anterior insula, and right declive.

Conclusions:
Thalamic connectivity to the bilateral lingual gyri and right middle temporal gyrus is a replicable finding in DN-RLS that was not affected by dopamine agonist treatments. Other changes in thalamic connectivity were altered by dopamine agonist treatment. These treatment effects may be pertinent to the known treatment benefits of a dopamine agonist on RLS symptoms.
Keimyung Author(s)(Kor)
김근태
장혁원
조용원
Publisher
School of Medicine (의과대학)
Citation
Yeong Seon Lee et al. (2020). Resting-state connectivity and the effects of treatment in restless legs syndrome. Sleep Medicine, 67, 33–38. doi: 10.1016/j.sleep.2019.10.014
Type
Article
ISSN
1878-5506
Source
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S138994571931545X
DOI
10.1016/j.sleep.2019.10.014
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43312
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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