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Association of Hepcidin With Anemia Parameters in Incident Dialysis Patients: Differences Between Dialysis Modalities

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Author(s)
Jeong-Hoon LimYeong Woo ParkSun Hee LeeJun Young DoSung-Ho KimSeungyeup HanHee-Yeon JungJi-Young ChoiJang-Hee ChoChan-Duck KimSun-Hee ParkYong-Lim Kim
Keimyung Author(s)
Han, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
Therapeutic Apheresis and Dialysis
Issued Date
2020
Volume
24
Issue
1
Keyword
End-stage renal diseaseHemoglobinHepcidinIron parameterUrine volume
Abstract
Hepcidin's relationships with other variables are unclear. We evaluated associations of serum hepcidin with clinical parameters in ESRD patients. Ninety-nine incident dialysis patients, including 57 on peritoneal dialysis (PD) and 42 on HD, were prospectively followed for 6 months. Serum hepcidin levels significantly increased during initial 6 months of dialysis. In the multivariate regression model, independent predictors of serum hepcidin levels in ESRD patients before maintenance dialysis were interleukin-6, ferritin, phosphate, iron, and aspartate transaminase. Six months after initiating dialysis, serum hepcidin levels were independently predicted by ferritin, total iron binding capacity (TIBC), and aspartate transaminase in all patients, whereas by ferritin and TIBC in PD patients, and ferritin, TIBC, and 24-h urine volume in HD patients. Serum hepcidin levels are differentially associated with anemia parameters in PD compared with HD patients. Urine volume was an independent predictor of hepcidin levels in early HD patients.
Keimyung Author(s)(Kor)
한승엽
Publisher
School of Medicine (의과대학)
Citation
Jeong-Hoon Lim et al. (2020). Association of Hepcidin With Anemia Parameters in Incident Dialysis Patients: Differences Between Dialysis Modalities. Therapeutic Apheresis and Dialysis, 24(1), 4–16. doi: 10.1111/1744-9987.12837
Type
Article
ISSN
1744-9987
Source
https://onlinelibrary.wiley.com/doi/full/10.1111/1744-9987.12837
DOI
10.1111/1744-9987.12837
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43319
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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