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Relationship Between Thyroid Hormone Levels and the Pathology of Alzheimer's Disease in Euthyroid Subjects

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Author(s)
Byung Wook ChoiShin KimSungmin KangKyoung Sook WonHyon-Ah YiHae Won Kim
Keimyung Author(s)
Kim, ShinWon, Kyoung SookYi, Hyon AhKim, Hae Won
Department
Dept. of Immunology (면역학)
Dept. of Neurology (신경과학)
Dept. of Nuclear Medicine (핵의학)
Journal Title
Thyroid
Issued Date
2020
Volume
30
Issue
11
Keyword
Alzheimer's diseaseamyloid-βsubclinical hypothyroidismthyroid hormonethyrotropin
Abstract
Background:
Although several studies have reported an association between thyroid dysfunction and Alzheimer's disease (AD), the effect of mild thyroid dysfunction within the normal range of thyrotropin (TSH) on the development of AD remains unclear. The aim of this study was to evaluate the association between thyroid hormones and the pathology of AD in euthyroid subjects.

Methods:
Sixty-nine subjects with a TSH level between 0.5 and 4.5 μIU/L who underwent 18F-florbetaben positron emission tomography were included in this prospective cross-sectional study. The levels of serum free thyroxine (fT4) and TSH were quantified using radioimmunoassay. Neuropsychological tests were performed to assess cognitive function. Differences in cerebral amyloid-β (Aβ) burden were compared between high-normal TSH (TSH ≥2.5 μIU/mL) and low-normal TSH (TSH <2.5 μIU/mL) groups. Multiple linear regression analyses, adjusted for age, sex, education level, and Neuropsychiatric Inventory scores, were performed to evaluate relationships between thyroid hormone levels and both cerebral Aβ burden and cognitive function.

Results:
The cerebral Aβ burden in the high-normal TSH group was significantly higher than in the low-normal TSH group (1.53 ± 0.31 vs. 1.35 ± 0.22, p = 0.009). The fT4 levels were negatively correlated with cerebral Aβ burden (β = -0.240, p = 0.035), and TSH levels were positively correlated with cerebral Aβ burden (β = 0.267, p = 0.020). The fT4 level was also positively associated with cognitive function, as inferred from neuropsychological test scores.

Conclusions:
Thyroid hormone concentrations were associated with AD pathology in euthyroid subjects. Our findings suggest that AD is likely to occur even in individuals with high-normal TSH levels.
Keimyung Author(s)(Kor)
김신
원경숙
이현아
김해원
Publisher
School of Medicine (의과대학)
Citation
Byung Wook Choi et al. (2020). Relationship Between Thyroid Hormone Levels and the Pathology of Alzheimer’s Disease in Euthyroid Subjects. Thyroid, 30(11), 1547–1555. doi: 10.1089/thy.2019.0727
Type
Article
ISSN
1557-9077
Source
https://www.liebertpub.com/doi/10.1089/thy.2019.0727
DOI
10.1089/thy.2019.0727
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43321
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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